E3 ubiquitin-protein ligase RNF31 (Rnf31) Recombinant Protein | Rnf31 recombinant protein

Recombinant Mouse E3 ubiquitin-protein ligase RNF31 (Rnf31) , partial

• Gene Names: Rnf31; HOIP; Paul; AL033293; BC031509; Flj10111; mFLJ00217
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: E3 ubiquitin-protein ligase RNF31 (Rnf31); Recombinant Mouse E3 ubiquitin-protein ligase RNF31 (Rnf31); partial; Rnf31 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,057

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Rnf31 recombinant protein

This protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.

NCBI and Uniprot Product Information

• NCBI GI #: 40254409
• NCBI GeneID: 268749
• NCBI Accession #: NP_919327.2
• NCBI GenBank Nucleotide #: NM_194346.2
• UniProt Accession #: Q924T7
• Molecular Weight: 118,148 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase RNF31
• NCBI Official Synonym Full Names: ring finger protein 31
• NCBI Official Symbol: Rnf31
• NCBI Official Synonym Symbols: HOIP; Paul; AL033293; BC031509; Flj10111; mFLJ00217
• NCBI Protein Information: E3 ubiquitin-protein ligase RNF31
• UniProt Protein Name: E3 ubiquitin-protein ligase RNF31
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: Rnf31
• UniProt Synonym Gene Names: PAUL

Uniprot Description

E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.