Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1) Recombinant Protein | KIR3DS1 recombinant protein

Recombinant Human Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1), partial

Cat. Num. AAA1440362

• Gene Names: KIR3DS1; KIR-G1; NKAT10; CD158E2; NKAT-10; KIR-123FM
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1); Recombinant Human Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1); partial; KIR3DS1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 22-340
• Sequence: HMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML YKEDRIHVPI FHGRIFQEGF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPMVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEWI SKDPSRLVGQ IHDGVSKANF SIGSMMRALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGL YEKPSLSAQP GPKVQAGESV TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNLRHLH
• Sequence Length: 319

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for KIR3DS1 recombinant protein

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

NCBI and Uniprot Product Information

• NCBI GI #: 134133244
• NCBI GeneID: 3813
• NCBI Accession #: NP_001077008.1
• NCBI GenBank Nucleotide #: NM_001083539.2
• UniProt Accession #: Q14943; Q5UCD2; A0A0G2JNN4
• Molecular Weight: 42,475 Da
• NCBI Official Full Name: killer cell immunoglobulin-like receptor 3DS1 isoform 1
• NCBI Official Synonym Full Names: killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1
• NCBI Official Symbol: KIR3DS1
• NCBI Official Synonym Symbols: KIR-G1; NKAT10; CD158E2; NKAT-10; KIR-123FM
• NCBI Protein Information: killer cell immunoglobulin-like receptor 3DS1
• UniProt Protein Name: Killer cell immunoglobulin-like receptor 3DS1
• Protein Family: Killer cell immunoglobulin-like receptor
• UniProt Gene Name: KIR3DS1
• UniProt Synonym Gene Names: NKAT10; NKAT-10

NCBI Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Uniprot Description

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.