Adenosine Kinase Recombinant Protein | ADK recombinant protein

Recombinant Human Adenosine Kinase

Cat. Num. AAA143939

• Gene Names: ADK; AK
• Purity: Greater than 95% as determined by SDS-PAGE.
• Synonyms: Adenosine Kinase; Recombinant Human Adenosine Kinase; ADK Human; Adenosine Kinase Human Recombinant; Adenosine 5''-phosphotransferase; EC 2.7.1.20; AK; ADK; ADK recombinant protein

• Host: Escherichia Coli
• Purity/Purification: Greater than 95% as determined by SDS-PAGE.
• Form/Format: ADK protein solution (0.5 mg/mL) containing 20 mM Tris-HCI pH-8,1 mM DTT, 1 mM EDTA, 50 mM NaCI & 20% glycerol.
• Sequence: MGSSHHHHHH SSGLVPRGSH MRENILFGMG NPLLDISAVV DKDFLDKYSL KPNDQILAED KHKELFDELV KKFKVEYHAG GSTQNSIKVA QWMIQQPHKA ATFFGCIGID KFGEILKRKA AEAHVDAHYY EQNEQPTGTC AACITGDNRS LIANLAAANC YKKEKHLDLE KNWMLVEKAR VCYIAGFFLT VSPESVLKVA HHASENNRIF TLNLSAPFIS QFYKESLMKV MPYVDILFGN ETEAATFARE QGFETKDIKE IAKKTQALPK MNSKRQRIVI FTQGRDDTIM ATESEVTAFA VLDQDQKEII DTNGAGDAFV GGFLSQLVSD KPLTECIRAG HYAASIIIRR TGCTFPEKPD FH
• Sequence Length: 345

• Physical Appearance: Sterile filtered colorless solution
• Preparation and Storage: Store at 4°C if entire viall will be used within 2-4 weeks.; Store, frozen at -20°C for longer periods of time.; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; Avoid multiple freeze/thaw cycles.

Related Product Information for ADK recombinant protein

Adenosine Kinase Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 362 amino acids (22-362a.a.) and having a molecular mass of 40.5 kDa. Adenosine Kinase protein is fused to a 21 amino acid His tag at N-terminus and is purified by standard chromatography.

Product Categories/Family for ADK recombinant protein

Protein Kinases; Enzymes; Adenylate Kinase

NCBI and Uniprot Product Information

• NCBI GI #: 32484973
• NCBI GeneID: 132
• NCBI Accession #: NP_001114.2
• NCBI GenBank Nucleotide #: NM_001123.3
• UniProt Accession #: P55263; O00741; O00742; Q16710; Q5JQ10; Q5JQ11; Q9BTN2; B7Z783; B7Z800
• NCBI Official Full Name: adenosine kinase isoform a
• NCBI Official Synonym Full Names: adenosine kinase
• NCBI Official Symbol: ADK
• NCBI Official Synonym Symbols: AK
• NCBI Protein Information: adenosine kinase; adenosine 5'-phosphotransferase
• UniProt Protein Name: Adenosine kinase
• Protein Family: Adenosine kinase
• UniProt Gene Name: ADK
• UniProt Synonym Gene Names: AK
• UniProt Entry Name: ADK_HUMAN

NCBI Description

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Uniprot Description

ADK: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. Defects in ADK are the cause of hypermethioninemia due to adenosine kinase deficiency (HMAKD). A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal. Belongs to the carbohydrate kinase PfkB family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.1.20; Nucleotide Metabolism - purine; Kinase, other

Chromosomal Location of Human Ortholog: 10q22|10q11-q24

Cellular Component: nucleoplasm; cytoplasm; cytosol

Molecular Function: metal ion binding; adenosine kinase activity; phosphotransferase activity, alcohol group as acceptor; ATP binding

Biological Process: nucleobase, nucleoside and nucleotide metabolic process; dATP biosynthetic process; ribonucleoside monophosphate biosynthetic process; positive regulation of T cell proliferation; circadian regulation of gene expression; adenosine metabolic process; phosphorylation; purine base metabolic process; purine salvage

Disease: Hypermethioninemia Due To Adenosine Kinase Deficiency