Receptor-type tyrosine-protein phosphatase-like N (Ptprn) Recombinant Protein | Ptprn recombinant protein

Recombinant Rat Receptor-type tyrosine-protein phosphatase-like N (Ptprn), partial

Cat. Num. AAA1434768

• Gene Names: Ptprn; Ia-2; ICA512
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Receptor-type tyrosine-protein phosphatase-like N (Ptprn); Recombinant Rat Receptor-type tyrosine-protein phosphatase-like N (Ptprn); partial; Ptprn recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 41-579
• Sequence: ISAHGCLFDR RLCSHLEVCI QDGLFGQCQA GVGQARPLLQ VTSPVLQRLQ GVLRQLMSQG LSWHDDLTQY VISQEMERIP RLRPPEPHPR DRSGSVPRRA GPAGELLSQG NPTGSSPAVQ GLSRPPGDGN GAGVGSPLSS LQAELLPPLL EHLLMPPQPP HPSLTYEPAL LQPYLFQQFG SRDGSRGSES ASGVVGHLAK AEDPVLFSRS LSKAILGTHS GHSFGDLTGP SPAQLFQDSG LLYMAQELPV PGRARAPRLP EEGGSSRAED SSEGHEEEVL GGHGEKSPPQ AVQADVSLQR LAAVLAGYGV ELRQLTPEQL STLLTLLQLL PKGTGRHLGG AVNGGADVKK TIEEQMQRGD TADARPPTPL LPGHPTASST SIKVRQVLSP GFPEPPKTSS PLGISAVLLE KKSPLGQSQP TVVGQPSARP SAEEYGYIVT DQKPLSLVAG VKLLEILAEH VHMTSGSFIN ISVVGPAVTF RIRHNEQNLS LADVTQQAGL VKSELEAQTG LQILQTGVGQ REESAAVLPR QAHGISPMR
• Sequence Length: 539

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Ptprn recombinant protein

This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.

NCBI and Uniprot Product Information

• NCBI GI #: 29789305
• NCBI GeneID: 116660
• NCBI Accession #: NP_446333.1
• NCBI GenBank Nucleotide #: NM_053881.1
• UniProt Accession #: Q63259; Q62883; Q63795; Q64643
• Molecular Weight: 106,228 Da
• NCBI Official Full Name: receptor-type tyrosine-protein phosphatase-like N
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, N
• NCBI Official Symbol: Ptprn
• NCBI Official Synonym Symbols: Ia-2; ICA512
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase-like N
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase-like N
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: Ptprn
• UniProt Synonym Gene Names: ICA512-NTF; ICA512-TMF; ICA512-CCF

NCBI Description

putative tyrosine phosphatase; involved in cytokine mediated signaling pathways [RGD, Feb 2006]

Uniprot Description

Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. Seems to lack intrinsic enzyme activity.