Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) Recombinant Protein | HOGA1 recombinant protein
Recombinant Human Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1)
NCBI and Uniprot Product Information
NCBI Description
The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
Uniprot Description
Catalyzes the final step in the metabolic pathway of hydroxyproline.
Research Articles on HOGA1
Similar Products
Product Notes
The HOGA1 hoga1 (Catalog #AAA1426606) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 26-327, Full length protein. The amino acid sequence is listed below: ASGEGKKVDI AGIYPPVTTP FTATAEVDYG KLEENLHKLG TFPFRGFVVQ GSNGEFPFLT SSERLEVVSR VRQAMPKNRL LLAGSGCEST QATVEMTVSM AQVGADAAMV VTPCYYRGRM SSAALIHHYT KVADLSPIPV VLYSVPANTG LDLPVDAVVT LSQHPNIVGM KDSGGDVTRI GLIVHKTRKQ DFQVLAGSAG FLMASYALGA VGGVCALANV LGAQVCQLER LCCTGQWEDA QKLQHRLIEP NAAVTRRFGI PGLKKIMDWF GYYGGPCRAP LQELSPAEEE ALRMDFTSNG WL. It is sometimes possible for the material contained within the vial of "Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
