Interleukin-1 receptor-associated kinase 4 (IRAK4) Recombinant Protein | IRAK4 recombinant protein
Recombinant Bovine Interleukin-1 receptor-associated kinase 4 (IRAK4)
NCBI and Uniprot Product Information
Uniprot Description
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections ().
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Product Notes
The IRAK4 irak4 (Catalog #AAA1426035) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-461, full length protein. The amino acid sequence is listed below: MNKPITASTY VRCLSLGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ FHIRRFEALL QIGKSPTCEL LFDWGTTNCT VGDLVDILVQ NEFFAPASLL LPDAVPKNVN TLPSKVTVVA VQQKPKPLCG KDRTSVISDE NPEQNYVLPD SSSPENTSLE FSDTRFHSFS FFELKDVTNN FDERPISVGG NKMGEGGFGV VYKGYVNNRT VAVKKLAAMV DISTEELKQQ FDQEIKVMAK CQHENLVELL GFSSDGDDLC LVYVYMPNGS LLDRLSCLDG TPPLSWNMRC KIAQGAANGL SYLHENHHIH RDIKSANILL DEDFTAKISD FGLARASEKF AQTVMTSRIV GTTAYMAPEA LRGEITPKSD IYSFGVVLLE IITGLPAVDE HREPQLLLDI KEEIEDEEKT IEDYVDRKMN DIDSTSIETM YSVASQCLHE KKNKRPDIKK VQQLLEEMTG S. It is sometimes possible for the material contained within the vial of "Interleukin-1 receptor-associated kinase 4 (IRAK4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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