WD repeat-containing protein 19 (WDR19) Recombinant Protein | WDR19 recombinant protein

Recombinant Human WD repeat-containing protein 19 (WDR19) , partial

• Gene Names: WDR19; ATD5; CED4; DYF-2; ORF26; Oseg6; PWDMP; SRTD5; IFT144; NPHP13
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: WD repeat-containing protein 19 (WDR19); Recombinant Human WD repeat-containing protein 19 (WDR19); partial; WDR19 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 481

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for WDR19 recombinant protein

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane domains. This gene is conserved from C. elegans to human. It may participate in androgen-regulated signaling mechanisms or in the vesicular trafficking of androgen-regulated secretory processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported but the full-length nature of one of these variants has not been defined.

NCBI and Uniprot Product Information

• NCBI GI #: 961658099
• NCBI GeneID: 57728
• NCBI Accession #: NP_001304853.1
• NCBI GenBank Nucleotide #: NM_001317924.1
• UniProt Accession #: Q8NEZ3; Q8N5B4; Q9H5S0; Q9HCD4; B5MEF2
• Molecular Weight: 53,573 Da
• NCBI Official Full Name: WD repeat-containing protein 19 isoform 2
• NCBI Official Synonym Full Names: WD repeat domain 19
• NCBI Official Symbol: WDR19
• NCBI Official Synonym Symbols: ATD5; CED4; DYF-2; ORF26; Oseg6; PWDMP; SRTD5; IFT144; NPHP13
• NCBI Protein Information: WD repeat-containing protein 19
• UniProt Protein Name: WD repeat-containing protein 19
• Protein Family: WD repeat-containing protein
• UniProt Gene Name: WDR19

NCBI Description

The protein encoded by this gene is a member of the WD (tryptophan-aspartic acid) repeat family, which is a large family of structurally-related proteins known to participate in a wide range of cellular processes. Each WD repeat typically contains about 40 amino acids that are usually bracketed by glycine-histidine and tryptophan-aspartic acid (WD) dipeptides. This protein contains six WD repeats, three transmembrane domains, and a clathrin heavy-chain repeat. Mutations in this gene have been described in individuals with a wide range of disorders affecting function of the cilium. These disorders are known as ciliopathies, and include Jeune syndrome, Sensenbrenner syndromes, Senior-Loken syndrome, combined or isolated nephronophthisis (NPHP), and retinitis pigmentosa (RP). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Description

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (PubMed:20889716). Involved in cilia function and/or assembly (). Associates with the BBSome complex to mediate ciliary transport ().