Probable methyltransferase TARBP1 (TARBP1) Recombinant Protein | TARBP1 recombinant protein

Recombinant Human Probable methyltransferase TARBP1 (TARBP1) , partial

• Gene Names: TARBP1; TRM3; TRMT3; TRP185; TRP-185
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Probable methyltransferase TARBP1 (TARBP1); Recombinant Human Probable methyltransferase TARBP1 (TARBP1); partial; TARBP1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1621

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for TARBP1 recombinant protein

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either This protein or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 110825988
• NCBI GeneID: 6894
• NCBI Accession #: NP_005637.3
• NCBI GenBank Nucleotide #: NM_005646.3
• UniProt Accession #: Q13395; Q9H581
• Molecular Weight: 181,675 Da
• NCBI Official Full Name: probable methyltransferase TARBP1
• NCBI Official Synonym Full Names: TAR (HIV-1) RNA binding protein 1
• NCBI Official Symbol: TARBP1
• NCBI Official Synonym Symbols: TRM3; TRMT3; TRP185; TRP-185
• NCBI Protein Information: probable methyltransferase TARBP1
• UniProt Protein Name: Probable methyltransferase TARBP1
• Protein Family: Probable methyltransferase
• UniProt Gene Name: TARBP1
• UniProt Synonym Gene Names: TRM3; TRP185; TRP-185

NCBI Description

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA.