E3 ubiquitin-protein ligase ZFP91 (ZFP91) Recombinant Protein | ZFP91 recombinant protein

Recombinant Human E3 ubiquitin-protein ligase ZFP91 (ZFP91)

• Gene Names: ZFP91; PZF; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: E3 ubiquitin-protein ligase ZFP91 (ZFP91); Recombinant Human E3 ubiquitin-protein ligase ZFP91 (ZFP91); E3 ubiquitin-protein ligase ZFP91; EC=6.3.2.-; Zinc finger protein 757; Zinc finger protein 91 homolog; Zfp-91; ZFP91 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 242-570. Partial
• Sequence: ETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEENEIREDEEPPRKRGRRRKDDKSPRLPKRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKYQHLLKKKYVCPHPSCGRLFRLQKQLLRHAKHHTDQRDYICEYCARAFKSSHNLAVHRMIHTGEKPLQCEICGFTCRQKASLNWHMKKHDADSFYQFSCNICGKKFEKKDSVVAHKAKSHPEVLIAEALAANAGALITSTDILGTNPESLTQPSDGQGLPLLPEPLGNSTSGECLLLEAEGMSKSYCSGTERVSLMADGKIFVGSGSSGGTEGLVMNSDILGATTEVLIEDSDSAGP
• Sequence Length: 570

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 308081964
• NCBI GeneID: 80829
• NCBI Accession #: NP_001183980.1
• NCBI GenBank Nucleotide #: NM_001197051.1
• UniProt Accession #: Q96JP5; Q86V47; Q96JP4; Q96QA3; A6NHC4; A8MSG7
• Molecular Weight: 59,571 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase ZFP91 isoform 2
• NCBI Official Synonym Full Names: ZFP91 zinc finger protein
• NCBI Official Symbol: ZFP91
• NCBI Official Synonym Symbols: PZF; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757
• NCBI Protein Information: E3 ubiquitin-protein ligase ZFP91; zinc finger protein 757; penta zinc finger protein; zinc finger protein 91 homolog; zinc finger protein homologous to Zfp91 in mouse; drug resistance-associated sequence in melanoma 8
• UniProt Protein Name: E3 ubiquitin-protein ligase ZFP91
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: ZFP91
• UniProt Synonym Gene Names: ZNF757; Zfp-91
• UniProt Entry Name: ZFP91_HUMAN

NCBI Description

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]

Uniprot Description

ZFP91: Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: nucleus

Molecular Function: nucleic acid binding; metal ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: activation of NF-kappaB-inducing kinase