Mouse anti-Human MAPK Scaffold Protein 1 Monoclonal Antibody | anti-MAPKSP1 antibody

Mouse Anti Human MAPK Scaffold Protein 1

Cat. Num. AAA141205

• Gene Names: LAMTOR3; MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3
• Reactivity: Human
• Purity: Purified from mouse ascitic fluids by Protein-A affinity chromatography.
• Synonyms: MAPK Scaffold Protein 1; Monoclonal Antibody; Mouse Anti Human MAPK Scaffold Protein 1; Mouse Anti Human; MAPBP; MP1; Interacting Protein 1; MEK binding partner 1; Mitogen-Activated Protein Kinase kinase 1; MAPKSP1 antibody; anti-MAPKSP1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b heavy chain and k light chain.
• Clone Number: PAT1F10AT.
• Purity/Purification: Purified from mouse ascitic fluids by Protein-A affinity chromatography.
• Form/Format: Sterile filtered colorless solution.; 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
• Sequence Length: 124

• Application Notes: The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
• Immunogen: Anti-human MAPKSP1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MAPKSP1 protein 1-124 amino acids purified from E. coli.
• Preparation and Storage: For 12 months store at -20 degree C. For 1 month store at 4 degree C.; Prevent freeze thaw cycles.

Related Product Information for anti-MAPKSP1 antibody

MAPKSP1 is a scaffold protein which operates in the extracellular signal-regulated kinase (ERK) cascade. MAPKSP1 protein is restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2.

Product Categories/Family for anti-MAPKSP1 antibody

Monoclonal/Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 20072808
• NCBI GeneID: 8649
• Molecular Weight: 12,941 Da
• NCBI Official Full Name: MAPK scaffold protein 1
• NCBI Official Synonym Full Names: late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
• NCBI Official Symbol: LAMTOR3
• NCBI Official Synonym Symbols: MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3
• NCBI Protein Information: ragulator complex protein LAMTOR3
• UniProt Protein Name: Ragulator complex protein LAMTOR3
• UniProt Gene Name: LAMTOR3
• UniProt Synonym Gene Names: MAP2K1IP1; MAPKSP1; Mp1

NCBI Description

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

Uniprot Description

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.