Phosphodiesterase 6H cGMP-Specific Cone Gamma Recombinant Protein | PDE6H recombinant protein

Recombinant Human Phosphodiesterase 6H cGMP-Specific Cone Gamma

Cat. Num. AAA141179

• Gene Names: PDE6H; RCD3; ACHM6
• Purity: Greater than 80% as determined by SDS-PAGE.
• Synonyms: Phosphodiesterase 6H cGMP-Specific Cone Gamma; Recombinant Human Phosphodiesterase 6H cGMP-Specific Cone Gamma; PDE6H Human; Phosphodiesterase 6H cGMP-Specific Cone Gamma Human Recombinant; Phosphodiesterase 6H; CGMP-Specific; Cone; Gamma; Retinal Cone Rhodopsin-Sensitive CGMP 3';5'-Cyclic Phosphodiesterase; Subunit Gamma; EC 3.1.4.35; EC 3.1.4.17; RCD3; GMP-PDE Gamma; ACHM6; PDE6H; PDE6H recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 80% as determined by SDS-PAGE.
• Form/Format: PDE6H protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol, 2mM DTT and 0.1mM PMSF.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSDNTTL PAPASNQGPT TPRKGPPKFK QRQTRQFKSK PPKKGVKGFGDDIPGMEGLG TDITVICPWE AFSHLELHEL AQFGII
• Sequence Length: 83

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Related Product Information for PDE6H recombinant protein

Introduction: PDE6H belongs to the rod/cone cGMP-PDE gamma subunit family, which selectively catalyze the hydrolysis of 3 cyclic phosphate bonds in adenosine and/or guanine 3,5 cyclic monophosphate (cAMP and/or cGMP). This family regulates the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDE6H is the inhibitory (or gamma)

Description: PDE6H Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 106 amino acids (1-83 a.a) and having a molecular mass of 11.5 kDa. PDE6H is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Categories/Family for PDE6H recombinant protein

Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 5453868
• NCBI GeneID: 5149
• NCBI Accession #: NP_006196.1
• NCBI GenBank Nucleotide #: NM_006205.2
• UniProt Accession #: Q13956; Q52LY7
• Molecular Weight: 9,074 Da
• NCBI Official Full Name: retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
• NCBI Official Synonym Full Names: phosphodiesterase 6H
• NCBI Official Symbol: PDE6H
• NCBI Official Synonym Symbols: RCD3; ACHM6
• NCBI Protein Information: retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
• UniProt Protein Name: Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
• Protein Family: Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE6H
• UniProt Synonym Gene Names: GMP-PDE gamma
• UniProt Entry Name: CNCG_HUMAN

Uniprot Description

PDE6H: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Defects in PDE6H are the cause of cone dystrophy retinal type 3A (RCD3A); also known as cone dystrophy with night blindness and supernormal rod responses. RCD3A is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. Belongs to the rod/cone cGMP-PDE gamma subunit family.

Protein type: EC 3.1.4.35; Inhibitor; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 12p13

Molecular Function: enzyme inhibitor activity; protein binding

Disease: Retinal Cone Dystrophy 3a