High Mobility Group Nucleosomal Binding Domain 3 Recombinant Protein | HMGN3 recombinant protein
Recombinant Human High Mobility Group Nucleosomal Binding Domain 3
Gene Names
HMGN3; TRIP7; PNAS-24; PNAS-25
Purity
Greater than 95% as determined by SDS-PAGE.
Synonyms
High Mobility Group Nucleosomal Binding Domain 3; Recombinant Human High Mobility Group Nucleosomal Binding Domain 3; HMGN3 Human; High Mobility Group Nucleosomal Binding Domain 3 Human Recombinant; TRIP7; TR-Interacting Protein 7; High Mobility Group Nucleosome-Binding Domain-Containing Protein 3; Thyroid Hormone Receptor Interacting Protein 7; Thyroid Receptor-Interacting Protein 7; Thyroid Hormone Receptor Interactor 7; PNAS-24; PNAS-25; TRIP-7; High mobility group nucleosome-binding domain-containing protein 3; HMGN3 recombinant protein
Host
E Coli
Purity/Purification
Greater than 95% as determined by SDS-PAGE.
Form/Format
HMGN3 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH7.0) and 10% glycerol.
Sterile filtered colorless solution.
Sterile filtered colorless solution.
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPKRKSP ENTEGKDGSK VTKQEPTRRS ARLSAKPAPP KPEPKPRKTSAKKEPGAKIS RGAKGKKEEK QEAGKEGTEN
Sequence Length
95
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Related Product Information for HMGN3 recombinant protein
Introduction: High Mobility Group Nucleosomal Binding Domain 3 (HMGN3), binds thyroid hormone receptor beta, however it occurs only in the presence of thyroid hormone. Thyroid hormone receptors are hormone-dependent transcription factors which regulate expression of a variety of particular target genes. HMGN3 is considered to reduce the compactness of the chromatin fiber in nucleosomes, in that way enhancing transcription from chromatin templates.
Description: HMGN3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 100 amino acids (1-77 a.a) and having a molecular mass of 10.8 kDa. HMGN3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Description: HMGN3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 100 amino acids (1-77 a.a) and having a molecular mass of 10.8 kDa. HMGN3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Categories/Family for HMGN3 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
8,378 Da
NCBI Official Full Name
high mobility group nucleosome-binding domain-containing protein 3 isoform c
NCBI Official Synonym Full Names
high mobility group nucleosomal binding domain 3
NCBI Official Symbol
HMGN3
NCBI Official Synonym Symbols
TRIP7; PNAS-24; PNAS-25
NCBI Protein Information
high mobility group nucleosome-binding domain-containing protein 3
UniProt Protein Name
High mobility group nucleosome-binding domain-containing protein 3
UniProt Gene Name
HMGN3
UniProt Synonym Gene Names
TRIP7; TR-interacting protein 7; TRIP-7
UniProt Entry Name
HMGN3_HUMAN
Uniprot Description
HMGN3: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. Belongs to the HMGN family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 6q14.1
Cellular Component: cytoplasm; nucleoplasm
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Product Notes
The HMGN3 hmgn3 (Catalog #AAA141166) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MGSMPK RKSP ENTEGKDGSK VTKQEPTRRS ARLSAKPAPP KPEPKPRKTS AKKEPGAKIS RGAKGKKEEK QEAGKEGTEN. It is sometimes possible for the material contained within the vial of "High Mobility Group Nucleosomal Binding Domain 3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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