Pyrin (Mefv) Recombinant Protein | Mefv recombinant protein
Recombinant Rat Pyrin (Mefv)
Gene Names
Mefv; pyrin
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Pyrin (Mefv); Recombinant Rat Pyrin (Mefv); Mefv recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-750, full length protein
Sequence
MANTRVDHLLNTLEELLPYELEKFKFKLHTTSLEKGHSRIPLSLVKMARPIKLTRLLLTYYGEEYAVRLTLQILRATNQRQLAEELHKATGPEHLTEENGVGGSVQSSAENKDKGVKGSDVLGEDEAQQNDDESDILPPIQAEVGKGPQKKSLAKRKDQRGPESLDSQTKPGARSAAPLYRRTLVTQSPGDKENRAGAQTPQNAQLCREAARNSTAMSQGGERSRRLKCICLQERSDPGVLKLPLTQKKENPQIQKLFRLKRKQEMAVSFVRETATLNGRTTGTLEKGVGIPEHSMMLDEETSRNMSSKISLTREKRCTASWTENGNGGPETPETLGETVSSILCDSCSPKVLLSLGEKLAQTPEDPASLGQAASKGRSRDKVACPLCHTQGELPAKACVQSSCSCSVAPGDPKASGRCSICFQCQSSRAGKSCEAQSPQFLPQCPRHMKQVQLLFCEDHREPICLICRLSQEHQGHRVRPIEEAALQYKEQIRKQLERLREMRGYVEEHKLPADKKAEDFLKQTETQKQRISCPLEKLFQFLEQQEQLFVTWLQELVQTIGKVRETYYTQVSLLDKLIGELEAKQDQPEWELMQDIGATLHRAETMTASELLGIPPGVKEKLHLLYQKSKSAEKNMQRFSEMLGSEMAFSASDVATREGCRPSTTKAQALIPTVHLKCDGAHTQDFDVILCAELEAGGSEPQDYLHPSSAQDTPELHEIHSQNNKRKFKSFLKWKPSFSRTDRCLRTCW
Sequence Length
750
Species
Rat
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Mefv recombinant protein
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
83,995 Da
NCBI Official Full Name
pyrin
NCBI Official Synonym Full Names
MEFV, pyrin innate immunity regulator
NCBI Official Symbol
Mefv
NCBI Official Synonym Symbols
pyrin
NCBI Protein Information
pyrin
UniProt Protein Name
Pyrin
Protein Family
UniProt Gene Name
Mefv
Uniprot Description
Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production. It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization.
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Product Notes
The Mefv mefv (Catalog #AAA1410178) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-750, full length protein. The amino acid sequence is listed below: MANTRVDHLL NTLEELLPYE LEKFKFKLHT TSLEKGHSRI PLSLVKMARP IKLTRLLLTY YGEEYAVRLT LQILRATNQR QLAEELHKAT GPEHLTEENG VGGSVQSSAE NKDKGVKGSD VLGEDEAQQN DDESDILPPI QAEVGKGPQK KSLAKRKDQR GPESLDSQTK PGARSAAPLY RRTLVTQSPG DKENRAGAQT PQNAQLCREA ARNSTAMSQG GERSRRLKCI CLQERSDPGV LKLPLTQKKE NPQIQKLFRL KRKQEMAVSF VRETATLNGR TTGTLEKGVG IPEHSMMLDE ETSRNMSSKI SLTREKRCTA SWTENGNGGP ETPETLGETV SSILCDSCSP KVLLSLGEKL AQTPEDPASL GQAASKGRSR DKVACPLCHT QGELPAKACV QSSCSCSVAP GDPKASGRCS ICFQCQSSRA GKSCEAQSPQ FLPQCPRHMK QVQLLFCEDH REPICLICRL SQEHQGHRVR PIEEAALQYK EQIRKQLERL REMRGYVEEH KLPADKKAED FLKQTETQKQ RISCPLEKLF QFLEQQEQLF VTWLQELVQT IGKVRETYYT QVSLLDKLIG ELEAKQDQPE WELMQDIGAT LHRAETMTAS ELLGIPPGVK EKLHLLYQKS KSAEKNMQRF SEMLGSEMAF SASDVATREG CRPSTTKAQA LIPTVHLKCD GAHTQDFDVI LCAELEAGGS EPQDYLHPSS AQDTPELHEI HSQNNKRKFK SFLKWKPSFS RTDRCLRTCW. It is sometimes possible for the material contained within the vial of "Pyrin (Mefv), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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