Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2) Recombinant Protein | LILRA2 recombinant protein

Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2), partial

Cat. Num. AAA1393703

• Gene Names: LILRA2; ILT1; LIR7; CD85H; LIR-7
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2); Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2); partial; LILRA2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 24-449
• Sequence: GHLPKPT LWAEPGSVII QGSPVTLRCQ GSLQAEEYHL YRENKSASWV RRIQEPGKNG QFPIPSITWE HAGRYHCQYY SHNHSSEYSD PLELVVTGAY SKPTLSALPS PVVTLGGNVT LQCVSQVAFD GFILCKEGED EHPQRLNSHS HARGWSWAIF SVGPVSPSRR WSYRCYAYDS NSPYVWSLPS DLLELLVPGV SKKPSLSVQP GPMVAPGESL TLQCVSDVGY DRFVLYKEGE RDFLQRPGWQ PQAGLSQANF TLGPVSPSHG GQYRCYSAHN LSSEWSAPSD PLDILITGQF YDRPSLSVQP VPTVAPGKNV TLLCQSRGQF HTFLLTKEGA GHPPLHLRSE HQAQQNQAEF RMGPVTSAHV GTYRCYSSLS SNPYLLSLPS DPLELVVSEA AETLSPSQNK TDSTTTSLGQ HPQDYTVEN
• Sequence Length: 426

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 590122030
• NCBI GeneID: 11027
• NCBI Accession #: NP_006857.2
• NCBI GenBank Nucleotide #: NM_006866.3
• UniProt Accession #: Q8N149; O75020
• Molecular Weight: 48,023 Da
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily A member 2 isoform b
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor A2
• NCBI Official Symbol: LILRA2
• NCBI Official Synonym Symbols: ILT1; LIR7; CD85H; LIR-7
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily A member 2
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily A member 2
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily
• UniProt Gene Name: LILRA2
• UniProt Synonym Gene Names: ILT1; LIR7; LIR-7

NCBI Description

This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]

Uniprot Description

Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061).