Eukaryotic translation initiation factor 3 subunit D (Eif3d) Recombinant Protein | Eif3d recombinant protein

Recombinant Rat Eukaryotic translation initiation factor 3 subunit D (Eif3d)

Cat. Num. AAA1392610

• Gene Names: Eif3d; Eif3s7
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Eukaryotic translation initiation factor 3 subunit D (Eif3d); Recombinant Rat Eukaryotic translation initiation factor 3 subunit D (Eif3d); Eif3d recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-548, full length protein
• Sequence: MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDETSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMVQFNLQTLPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGRERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSEEDEEDEEEEEEEEEEEET
• Sequence Length: 548

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Eif3d recombinant protein

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2
GTP
methionyl-tRNA, and by promoting mRNA binding. This protein is the major RNA binding subunit of the eIF3 complex.

NCBI and Uniprot Product Information

• NCBI GI #: 51948536
• NCBI GeneID: 362952
• NCBI Accession #: NP_001004283.1
• NCBI GenBank Nucleotide #: NM_001004283.1
• UniProt Accession #: Q6AYK8
• Molecular Weight: 63,989 Da
• NCBI Official Full Name: eukaryotic translation initiation factor 3 subunit D
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 3, subunit D
• NCBI Official Symbol: Eif3d
• NCBI Official Synonym Symbols: Eif3s7
• NCBI Protein Information: eukaryotic translation initiation factor 3 subunit D
• UniProt Protein Name: Eukaryotic translation initiation factor 3 subunit D
• Protein Family: Eukaryotic translation initiation factor
• UniProt Gene Name: Eif3d
• UniProt Synonym Gene Names: Eif3s7; eIF3d

Uniprot Description

mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.