Splicing factor U2AF 26 kDa subunit (U2af1l4) Recombinant Protein | U2af1l4 recombinant protein
Recombinant Mouse Splicing factor U2AF 26 kDa subunit (U2af1l4)
NCBI and Uniprot Product Information
Uniprot Description
RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. It can functionally substitute for U2AF1 in constitutive splicing and enhancer-dependent splicing. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA (PubMed:11739736, PubMed:16819553, PubMed:18460468). Alternative splicing of U2AF1L4 may play a role in connecting the circadian rhythm to changing external cues: may provide a circadian buffering system in central and periphery clocks that allows synchronized adaption to clock-resetting stimuli in order to prevent potentially pathogenic desynchronization (PubMed:24837677).
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Product Notes
The U2af1l4 u2af1l4 (Catalog #AAA1378831) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-220, full length protein. The amino acid sequence is listed below: AEYLASIFGT EKDKVNCSFY FKIGACRHGD RCSRLHNKPT FSQTIVLLNL YRNPQNTAQT ADGSHCHVSD VEVQEHYDNF FEEVFTELQE KYGEIEEMNV CDNLGDHLVG NVYVKFRREE DAERAVAELN NRWFNGQAVH AELSPVTDFR ESCCRQYEMG ECTRGGFCNF MHLRPISRNL RRQLYGRGPR HRSPPRSHTG HRPRERNRRR SPDHRHGRF. It is sometimes possible for the material contained within the vial of "Splicing factor U2AF 26 kDa subunit (U2af1l4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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