FYVE, RhoGEF and PH domain-containing protein 4 (Fgd4) Recombinant Protein | Fgd4 recombinant protein

Recombinant Mouse FYVE, RhoGEF and PH domain-containing protein 4 (Fgd4)

Cat. Num. AAA1371944

• Gene Names: Fgd4; Frabp; ZFYVE6; 9030023J02Rik; 9330209B17Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: FYVE; RhoGEF and PH domain-containing protein 4 (Fgd4); Recombinant Mouse FYVE; Fgd4 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-766, Full length protein
• Sequence: MEESNPAPTSCTSKGKHSKVSDLISHFEGGSVLSSYIDLQKDSTMNLNIPQTLGQPGLTSSPPRKFLPQHSPQKQENDPDQTQGQHGCLANGVVAAQNQMECEDEKETTLSPEMAIQTAAASPDTHVLNGERNETITDSASSIANSHDENASDSSCRTPGTDLGLPSKEGEPGMDAELQERENGVNTMGLDTLDQHHEVKETNEQKLHKIATELLLTERAYVSRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAVELVKTMTERVPQFKSVTEEIQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDSPDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPRFSLVGSKFTVRTRVGIDGMKIVETHNEEYPHTFQISGKERTLELQASSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVSTAELGKRAPRWIRDNEVTMCMKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKDCYQIISGFTDSEEKKRRGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDDMPKSADLPHSFKLTQSKSVHSFAADNEELKQKWLKIILLAVTGETPDGPSEHLATLNNLPGPKKKSEC
• Sequence Length: 766

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Fgd4 recombinant protein

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system.

NCBI and Uniprot Product Information

• NCBI GI #: 685504963
• NCBI GeneID: 224014
• NCBI Accession #: NP_001288747.1
• NCBI GenBank Nucleotide #: NM_001301818.1
• UniProt Accession #: Q91ZT5; Q3UEB6; Q8BW60; Q8BZI7; Q91ZT3; Q91ZT4; A1L355
• Molecular Weight: 52,016 Da
• NCBI Official Full Name: FYVE, RhoGEF and PH domain-containing protein 4 isoform alpha
• NCBI Official Synonym Full Names: FYVE, RhoGEF and PH domain containing 4
• NCBI Official Symbol: Fgd4
• NCBI Official Synonym Symbols: Frabp; ZFYVE6; 9030023J02Rik; 9330209B17Rik
• NCBI Protein Information: FYVE, RhoGEF and PH domain-containing protein 4
• UniProt Protein Name: FYVE, RhoGEF and PH domain-containing protein 4
• Protein Family: FYVE, RhoGEF and PH domain-containing protein
• UniProt Gene Name: Fgd4

NCBI Description

This gene is a member of the FYVE, RhoGEF and PH domain containing (FGD) family. The encoded protein is a Cdc42-specific guanine nucleotide exchange factor (GEF) that plays an essential role in regulating the actin cytoskeleton and cell morphology. Disruption of the gene in mouse causes abnormal nerve development and dysmyelination. Mutations in a similar gene in human can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Uniprot Description

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates MAPK8 (). Plays a role in regulating the actin cytoskeleton and cell shape. Promotes the formation of lamellipodia.