Grainyhead-like protein 3 homolog (Grhl3) Recombinant Protein | Grhl3 recombinant protein

Recombinant Mouse Grainyhead-like protein 3 homolog (Grhl3)

Cat. Num. AAA1368197

• Gene Names: Grhl3; ct; Som; Get1; Tfcp2l4; AI561912
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Grainyhead-like protein 3 homolog (Grhl3); Recombinant Mouse Grainyhead-like protein 3 homolog (Grhl3); Grhl3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-603, Full length protein
• Sequence: MSNELDFRSVRLLKNDPVSFQKFPYSNEDEAWKTYLENPLTAATKAMMRVNGDEESVAALSFLYDYYMGPKEKRILSSSTGGRNDQGKKFYHSMDYEPDLAPLESPTHLMKFLTENVSGSPDYTDQLKKNNLLGLEGVLPTPGKTNTVPPGPSKLEASSMDSYLLPASDIYDNGSLNSLFESIHGVPPTQRWQPDSTFKDDPQESLLFPDILKTSPDPPCPEDYPGLKSDFEYTLGSPKAIHIKAGESPMAYLNKGQFYPVTLRTPAGGKGLALSSSKVKSVVMVVFDNDKVPVEQLRFWRHWHSRQPTAKQRVIDVADCKENFNTVQHIEEVAYNALSFVWNVNEEAKVFIGVNCLSTDFSSQKGVKGVPLNLQIDTYDCGAGTERLVHRAVCQIKIFCDKGAERKMRDDERKQFRRKVKCPDSSNNAGIKGCLLSGFRGNETTYLRPETDLETQPVLFIPNLHFSSLQRPGGVVPSAGHSSSDRLPLKRTCSPFAEEFEPLPSKQAKEDDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGLPEENICKVYKKCKRGILVNMDNNIIQHYSNHVAFLLDMGELDGKIQIILKEL
• Sequence Length: 603

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Grhl3 recombinant protein

This gene encodes a member of the grainyhead family of transcription factors. The encoded protein interacts with leader-binding protein 32 (LBP-32) and brother of mammalian grainyhead (BOM), and may function as a transcription factor during development. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional transcript variants have been described, but their biological nature has not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 71480136
• NCBI GeneID: 230824
• NCBI Accession #: NP_001013778.1
• NCBI GenBank Nucleotide #: NM_001013756.1
• UniProt Accession #: Q5FWH3; A2ADI2
• Molecular Weight: 67,816 Da
• NCBI Official Full Name: grainyhead-like protein 3 homolog
• NCBI Official Synonym Full Names: grainyhead like transcription factor 3
• NCBI Official Symbol: Grhl3
• NCBI Official Synonym Symbols: ct; Som; Get1; Tfcp2l4; AI561912
• NCBI Protein Information: grainyhead-like protein 3 homolog
• UniProt Protein Name: Grainyhead-like protein 3 homolog
• Protein Family: Grainyhead-like protein
• UniProt Gene Name: Grhl3

Uniprot Description

Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. Essential for epidermal differentiation and barrier formation at the end of embryogenesis with TGM3 as critical direct target (PubMed:21081122, PubMed:20654612, PubMed:25347468). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair (PubMed:21081122). Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury (PubMed:25347468). Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (PubMed:14608380, PubMed:20654612). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL1, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122).