Ephrin type-A receptor 1 (Epha1) Recombinant Protein | Epha1 recombinant protein

Recombinant Mouse Ephrin type-A receptor 1 (Epha1), partial

Cat. Num. AAA1363494

• Gene Names: Epha1; Eph; Esk; AL033318; 5730453L17Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ephrin type-A receptor 1 (Epha1); Recombinant Mouse Ephrin type-A receptor 1 (Epha1); partial; Epha1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 27-548
• Sequence: EEVT LMDTSTAQGE LGWLLDPPET GWSEVQQMLN GTPLYMYQDC PIQEGGDTDH WLRSNWIYRG EEASRIYVEL QFTVRDCKSF PGGAGPLGCK ETFNLFYMES DQDVGIQLRR PLFQKVTTVA ADQSFTIRDL ASGSVKLNVE RCSLGHLTRR GLYLAFHNPG SCVALVSVRV FYQRCAETVH GLAHFPDTLP GPGGLVEVAG TCLSHAQISL GSSGTPRMHC SPDGEWLVPV GQCQCEPGYE ESSGNVGCTA CPTGFYRVDM NTLRCLKCPQ HSIAESEGST ICTCENGHYR APGEGPQVAC TRPPSAPQNL SFSTSGTQLS LRWEPPRDTG GRHDIRYSVE CLQCRGIAQD GGPCQPCGKG VHFSPAASGL TTSTVQVQGL EPYANYTFTV KSQNRVSGLD SSSPSSASLS INMGHAESLS GLSLKLVKKE PRQLELTWAG SRPRNPGGNL SYELHVLNQD EEWHQMVLEP RVLLTKLQPD TTYIVRVRTL TPLGPGPFSP DHEFRTSPPV SRSLTGGE
• Sequence Length: 522

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Epha1 recombinant protein

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 31980651
• NCBI GeneID: 13835
• NCBI Accession #: NP_076069.2
• NCBI GenBank Nucleotide #: NM_023580.4
• UniProt Accession #: Q60750; Q8CED9; Q9ESJ2
• Molecular Weight: 108,578 Da
• NCBI Official Full Name: ephrin type-A receptor 1
• NCBI Official Synonym Full Names: Eph receptor A1
• NCBI Official Symbol: Epha1
• NCBI Official Synonym Symbols: Eph; Esk; AL033318; 5730453L17Rik
• NCBI Protein Information: ephrin type-A receptor 1
• UniProt Protein Name: Ephrin type-A receptor 1
• Protein Family: Ephrin type-A receptor
• UniProt Gene Name: Epha1
• UniProt Synonym Gene Names: Esk; mEpha1

Uniprot Description

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.