Ubiquitin carboxyl-terminal hydrolase 19 (Usp19) Recombinant Protein | Usp19 recombinant protein

Recombinant Rat Ubiquitin carboxyl-terminal hydrolase 19 (Usp19) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ubiquitin carboxyl-terminal hydrolase 19 (Usp19); Recombinant Rat Ubiquitin carboxyl-terminal hydrolase 19 (Usp19); partial; Usp19 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,357

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 48040522
• NCBI GeneID: 361190
• NCBI Accession #: NP_001001516.1
• NCBI GenBank Nucleotide #: NM_001001516.2
• UniProt Accession #: Q6J1Y9
• Molecular Weight: 150,302 Da
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase 19
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 19
• NCBI Official Symbol: Usp19
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 19
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 19
• UniProt Gene Name: Usp19

Uniprot Description

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing thier ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains ().