Pre-mRNA-processing factor 19 (Prpf19) Recombinant Protein | Prpf19 recombinant protein
Recombinant Rat Pre-mRNA-processing factor 19 (Prpf19)
NCBI and Uniprot Product Information
NCBI Description
human homolog is involved in DNA double strand break repair [RGD, Feb 2006]
Uniprot Description
Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries. The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair. Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response. May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA. As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process. In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (). May play a role in the biogenesis of lipid droplets (). May play a role in neural differentiation possibly through its function as part of the spliceosome (PubMed:16352598).
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Product Notes
The Prpf19 prpf19 (Catalog #AAA1360680) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-504, full length protein. The amino acid sequence is listed below: SLICSISNEV PEHPCVSPVS NHVYERRLIE KYIAENGTDP INNQPLSEEQ LIDIKVAHPI RPKPPSATSI PAILKALQDE WDAVMLHSFT LRQQLQTTRQ ELSHALYQHD AACRVIARLT KEVTAAREAL ATLKPQAGLI VPQAVPSSQP SVVGAGEPMD LGELVGMTPE IIQKLQDKAT VLTTERKKRG KTVPEELVKP EELSKYRQVA SHVGLHSASI PGILALDLCP SDTNKILTGG ADKNVVVFDK STEQILATLK GHTKKVTSVV FHPSQELVFS ASPDATIRIW SVPNTSCVQV VRAHESAVTG LSLHATGDYL LSSSDDQYWA FSDIQTGRVL TKVTDETSGC SLTCAQFHPD GLIFGTGTMD SQIKIWDLKE RTNVANFPGH SGPITSIAFS ENGYYLATAA DDSSVKLWDL RKLKNFKTLQ LDNNFEVKSL IFDQSGTYLA LGGTDVQIYI CKQWTEILHF TEHSGLTTGV AFGHHAKFIA STGMDRSLKF YSL. It is sometimes possible for the material contained within the vial of "Pre-mRNA-processing factor 19 (Prpf19), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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