Prorenin, C-terminal 8x His tag Protein | REN protein
Rat Prorenin, C-terminal 8x His tag
NCBI and Uniprot Product Information
NCBI Description
catalyzes the cleavage of a Leu-Xaa bond in angiotensinogen to generate angiotensin [RGD, Feb 2006]
Uniprot Description
REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.23.15; Secreted; Protease; Secreted, signal peptide
Cellular Component: extracellular space; membrane; cytoplasm; intracellular
Molecular Function: peptidase activity; insulin-like growth factor receptor binding; endopeptidase activity; aspartic-type endopeptidase activity; receptor binding
Biological Process: response to drug; response to cAMP; hormone-mediated signaling; establishment of blood-nerve barrier; male gonad development; cell maturation; drinking behavior; renin-angiotensin regulation of aldosterone production; response to lipopolysaccharide; angiotensin maturation; proteolysis; response to organic substance; beta-amyloid metabolic process; regulation of blood pressure; regulation of MAPKKK cascade; renin-angiotensin regulation of blood volume; mesonephros development; kidney development
Research Articles on REN
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Product Notes
The REN ren1 (Catalog #AAA135669) is a Protein produced from Human Embryonic Kidney cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Prorenin, C-terminal 8x His tag, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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