Fibroblast growth factor receptor 4 (FGFR4) Recombinant Protein | FGFR4 recombinant protein
Recombinant Coturnix coturnix Fibroblast growth factor receptor 4 (FGFR4), partial
NCBI and Uniprot Product Information
Uniprot Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 ().
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Product Notes
The FGFR4 fgfr4 (Catalog #AAA1334140) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 21-281. The amino acid sequence is listed below: HRGEMEPDSL ASGDDDEDSD GDGPHGDRSE EPVYMHRAPY WTHPHRMDKK LYAVPAGNTV KFRCPASGSP SPSIRWFKNG REFRGEHRIG GIRLRHQHWS LVMESVVPSD RGNYTCLVEN RFGRIRYSYL LDVLERSPHR PILQAGLPAN TTALVGSDVE FFCKVYSDAQ PHLQWLKHIE VNGSSYGPDG VPYVQVLKTA DINSSEVEVL YLRNVTMEDA GEYTCLAGNS IGLSYQSAWL TVLPEEELVH EAETSEAKYT D. It is sometimes possible for the material contained within the vial of "Fibroblast growth factor receptor 4 (FGFR4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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