Putative cytidine monophosphate-N-acetylneuraminic acid hydroxylase-like protein (CMAHP) Recombinant Protein | CMAHP recombinant protein
Recombinant Human Putative cytidine monophosphate-N-acetylneuraminic acid hydroxylase-like protein (CMAHP)
NCBI and Uniprot Product Information
NCBI Description
Sialic acids are terminal components of the carbohydrate chains of glycoconjugates involved in ligand-receptor, cell-cell, and cell-pathogen interactions. The two most common forms of sialic acid found in mammalian cells are N-acetylneuraminic acid (Neu5Ac) and its hydroxylated derivative, N-glycolylneuraminic acid (Neu5Gc). Studies of sialic acid distribution show that Neu5Gc is not detectable in normal human tissues although it was an abundant sialic acid in other mammals. Neu5Gc is, in actuality, immunogenic in humans. The absense of Neu5Gc in humans is due to a deletion within the human gene CMAH encoding cytidine monophosphate-N-acetylneuraminic acid hydroxylase, an enzyme responsible for Neu5Gc biosynthesis. Sequences encoding the mouse, pig, and chimpanzee hydroxylase enzymes were obtained by cDNA cloning and found to be highly homologous. However, the homologous human cDNA differs from these cDNAs by a 92-bp deletion in the 5' region. This deletion, corresponding to exon 6 of the mouse hydroxylase gene, causes a frameshift mutation and premature termination of the polypeptide chain in human. It seems unlikely that the truncated human hydroxylase mRNA encodes for an active enzyme explaining why Neu5Gc is undetectable in normal human tissues. Human genomic DNA also shows evidence of this deletion which does not occur in the genomes of African great apes. Nonetheless, the CMAH gene maps to 6p21.32 in humans and great apes indicating that mutation of the CMAH gene occurred following human divergence from chimpanzees and bonobos. [provided by RefSeq, Jul 2008]
Uniprot Description
Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells in vertebrates (PubMed:9624188). However, it may play a role in Wnt signaling (PubMed:19890979).
Research Articles on CMAHP
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Product Notes
The CMAHP cmahp (Catalog #AAA1329791) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-501aa; Full Length. The amino acid sequence is listed below: MDENNGLLLL ELNPPNPWDL QPRSPEELAF GEVQITYLTH ACMDLKLGDK RMVFDPWLIG PAFARGWWLL HEPPSDWLER LCQADLIYIS HLHSDHLSYP TLKKLAGRRP DIPIYVGNTE RPVFWNLNQS GVQLTNINVV PFGIWQQVDK NLRFMILMDG VHPEMDTCII VEYKGHKILN IVDCTRPNGG RLPMKVALMM SDFAGGASGF PMTFSGGKFT EEWKAQFIKT ERKKLLNYKA RLVKNLQPRI YCPFAGYFVE SHPSDKYIKE TNTKNDPNEL NNLIKKNSDV ITWTPRPGAT LDLGRMLKDR TDSKGIIEPP EGTKIYKDSW DFEPYLEILN AALGDEIFLH SSWIKEYFTW AGFKDYNLVV RMIETDEDFN PFPGGYDYLV DFLDLSFPKE RPQREHPYEE IHSRVDVIRH VVKNGLLWDE LYIGFQTRLQ RDPDIYHHLF WNHFQIKLPL TPPNWKSFLM CCEQNGPVIL QFSTERTNEP NR NKFSVE NKA . It is sometimes possible for the material contained within the vial of "Putative cytidine monophosphate-N-acetylneuraminic acid hydroxylase-like protein (CMAHP), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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