KN motif and ankyrin repeat domain-containing protein 1 (KANK1) Recombinant Protein | KANK1 recombinant protein

Recombinant Human KN motif and ankyrin repeat domain-containing protein 1 (KANK1) , partial

• Gene Names: KANK1; KANK; CPSQ2; ANKRD15
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: KN motif and ankyrin repeat domain-containing protein 1 (KANK1); Recombinant Human KN motif and ankyrin repeat domain-containing protein 1 (KANK1); partial; KANK1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,194

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for KANK1 recombinant protein

This gene encodes a protein containing four ankyrin repeat domains in its C-terminus. The suggested role for this protein is in tumorigenesis of renal cell carcinoma. Two alternatively spliced transcript variants encoding different isoforms have been identified.

NCBI and Uniprot Product Information

• NCBI GI #: 379056374
• NCBI GeneID: 23189
• NCBI Accession #: NP_001243805.1
• NCBI GenBank Nucleotide #: NM_001256876.2
• UniProt Accession #: Q14678; Q5W0W0; Q8IY65; Q8WX74; A2A2W8; D3DRH3
• Molecular Weight: 129,782 Da
• NCBI Official Full Name: KN motif and ankyrin repeat domain-containing protein 1 isoform L
• NCBI Official Synonym Full Names: KN motif and ankyrin repeat domains 1
• NCBI Official Symbol: KANK1
• NCBI Official Synonym Symbols: KANK; CPSQ2; ANKRD15
• NCBI Protein Information: KN motif and ankyrin repeat domain-containing protein 1
• UniProt Protein Name: KN motif and ankyrin repeat domain-containing protein 1
• Protein Family: KN motif and ankyrin repeat domain-containing protein
• UniProt Gene Name: KANK1
• UniProt Synonym Gene Names: ANKRD15; KANK; KIAA0172

NCBI Description

The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]

Uniprot Description

Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.