Atrial natriuretic peptide-converting enzyme (CORIN) Recombinant Protein | CORIN recombinant protein
Recombinant Human Atrial natriuretic peptide-converting enzyme (CORIN) , partial
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Uniprot Description
Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.Isoform 2: has weaker endopeptidase activity compared to isoform 1.MiscellaneousInitially named CORIN due to its abundant expression in the heart.
Research Articles on CORIN
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Product Notes
The CORIN corin (Catalog #AAA1319963) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 802-1042, Fragment at the C-terminal, provide the Atrial natriuretic peptide-converting enzyme, activated protease fragment. The amino acid sequence is listed below: ILGGRTSRPG RWPWQCSLQS EPSGHICGCV LIAKKWVLTV AHCFEGRENA AVWKVVLGIN NLDHPSVFMQ TRFVKTIILH PRYSRAVVDY DISIVELSED ISETGYVRPV CLPNPEQWLE PDTYCYITGW GHMGNKMPFK LQEGEVRIIS LEHCQSYFDM KTITTRMICA GYESGTVDSC MGDSGGPLVC EKPGGRWTLF GLTSWGSVCF SKVLGPGVYS NVSYFVEWIK RQIYIQTFLL N . It is sometimes possible for the material contained within the vial of "Atrial natriuretic peptide-converting enzyme (CORIN), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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