Parafibromin (CDC73) Recombinant Protein | CDC73 recombinant protein

Recombinant Chicken Parafibromin (CDC73), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Parafibromin (CDC73); Recombinant Chicken Parafibromin (CDC73); partial; CDC73 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 531

• Species: Chicken
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for CDC73 recombinant protein

This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3 mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.

NCBI and Uniprot Product Information

• NCBI GI #: 71895241
• NCBI GeneID: 424356
• NCBI Accession #: NP_001026436.1
• NCBI GenBank Nucleotide #: NM_001031265.1
• UniProt Accession #: Q5ZLM0
• Molecular Weight: 60,698 Da
• NCBI Official Full Name: parafibromin
• NCBI Official Synonym Full Names: cell division cycle 73
• NCBI Official Symbol: CDC73
• NCBI Protein Information: parafibromin
• UniProt Protein Name: Parafibromin
• Protein Family: Protein
• UniProt Gene Name: CDC73

Uniprot Description

Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) ().