Muscleblind-like protein 2 (MBNL2) Recombinant Protein | MBNL2 recombinant protein

Recombinant Human Muscleblind-like protein 2 (MBNL2)

Cat. Num. AAA1311690

• Gene Names: MBNL2; MBLL; MBLL39; PRO2032
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Muscleblind-like protein 2 (MBNL2); Recombinant Human Muscleblind-like protein 2 (MBNL2); MBNL2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-373, Full length protein
• Sequence: MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHPVPTFPVGPAIGTNTAISFAPYLAPVTPGVGLVPTEILPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTSDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMAFPPGALHPLPKRQALEKSNGTSAVFNPSVLHYQQALTSAQLQQHAAFIPTGSVLCMTPATSIDNSEIISRNGMECQESALRITKHCYCTYYPVSSSIELPQTAC
• Sequence Length: 373

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for MBNL2 recombinant protein

This gene encodes a C3H-type zinc finger protein, which is similar to the Drosophila melanogaster muscleblind B protein. Drosophila muscleblind is a gene required for photoreceptor differentiation. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 807045900
• NCBI GeneID: 10150
• NCBI Accession #: NP_001292999.1
• NCBI GenBank Nucleotide #: NM_001306070.1
• UniProt Accession #: Q5VZF2; Q3SXY5; Q58F19; Q8NEV3; Q8TD82
• Molecular Weight: 39,356 Da
• NCBI Official Full Name: muscleblind-like protein 2 isoform 4
• NCBI Official Synonym Full Names: muscleblind like splicing regulator 2
• NCBI Official Symbol: MBNL2
• NCBI Official Synonym Symbols: MBLL; MBLL39; PRO2032
• NCBI Protein Information: muscleblind-like protein 2
• UniProt Protein Name: Muscleblind-like protein 2
• Protein Family: Muscleblind-like protein
• UniProt Gene Name: MBNL2
• UniProt Synonym Gene Names: MBLL; MBLL39; MLP1

NCBI Description

This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. [provided by RefSeq, Mar 2012]

Uniprot Description

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).