Interferon-induced protein with tetratricopeptide repeats 3 (Ifit3) Recombinant Protein | Ifit3 recombinant protein
Recombinant Mouse Interferon-induced protein with tetratricopeptide repeats 3 (Ifit3)
Gene Names
Ifit3; P49; Ifi49
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Interferon-induced protein with tetratricopeptide repeats 3 (Ifit3); Recombinant Mouse Interferon-induced protein with tetratricopeptide repeats 3 (Ifit3); Ifit3 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-403, full length protein
Sequence
MSEVNRESLEAILPQLKCHFTWNLFREGSMSSHMEDRVCNQVEHLNSEEKATMYDLLAYIKHLDGESKAALECLGQAEDLRKSEHNDQSEIRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMECPELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEKQFSVDALKQAMELNPQNQYLKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYSLVMCRYREILEQLQNKGDADSSERRQRMAELRRLTMEFMQKTLQRRRSPLNSYSDLIDFPEVERCYQMVISKESPDVEEEDLYERYCNLQEYHRKSEDLAALECLLQFPRNERSIEKEEVKEQT
Sequence Length
403
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
47,223 Da
NCBI Official Full Name
interferon-induced protein with tetratricopeptide repeats 3
NCBI Official Synonym Full Names
interferon-induced protein with tetratricopeptide repeats 3
NCBI Official Symbol
Ifit3
NCBI Official Synonym Symbols
P49; Ifi49
NCBI Protein Information
interferon-induced protein with tetratricopeptide repeats 3
UniProt Protein Name
Interferon-induced protein with tetratricopeptide repeats 3
Protein Family
UniProt Gene Name
Ifit3
UniProt Synonym Gene Names
Garg49; Ifi49; Isg49; IFIT-3; GARG-49; P49
Uniprot Description
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2 ().
Research Articles on Ifit3
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Product Notes
The Ifit3 ifit3 (Catalog #AAA1308546) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-403, full length protein. The amino acid sequence is listed below: MSEVNRESLE AILPQLKCHF TWNLFREGSM SSHMEDRVCN QVEHLNSEEK ATMYDLLAYI KHLDGESKAA LECLGQAEDL RKSEHNDQSE IRRLVTWGNY AWIYYHMGRL SEAQAYVDKV RQVCQKFANP YSMECPELEC EEGWTRLKCG RNERAKMCFE KALEEKPKDP ECSSGMAIAM FRLEEKPEKQ FSVDALKQAM ELNPQNQYLK VLLALKLLRM GEEAEGERLI KDALGKAPNQ TDVLQKAAQF YKKKGNLDRA IELLGKALRS TVNNSPLYSL VMCRYREILE QLQNKGDADS SERRQRMAEL RRLTMEFMQK TLQRRRSPLN SYSDLIDFPE VERCYQMVIS KESPDVEEED LYERYCNLQE YHRKSEDLAA LECLLQFPRN ERSIEKEEVK EQT. It is sometimes possible for the material contained within the vial of "Interferon-induced protein with tetratricopeptide repeats 3 (Ifit3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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