Peptidoglycan-recognition protein LE (PGRP-LE) Recombinant Protein | PGRP-LE recombinant protein
Recombinant Drosophila melanogaster Peptidoglycan-recognition protein LE (PGRP-LE)
Gene Names
PGRP-LE; anon-WO0153538.66; CG8995; DmelCG8995; PGRP; pgrp le; pgrp-le
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Peptidoglycan-recognition protein LE (PGRP-LE); Recombinant Drosophila melanogaster Peptidoglycan-recognition protein LE (PGRP-LE); PGRP-LE recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-345, Full length protein
Sequence
MSESGIKKLSQERTREWLASQEDEELESIAESSVVDSLDYDYTEEEEDADQNTSEEISTMTLGTQIATKKHSIISDTIRDLMNSINSIQTLGNVNISNSTNVHIGNVTNINGNIQIIADGLTQNRRDRRHVSPPRDNAPKTPTHFEDDYQDESEERVRSDVFIRRQKFKIPKELSAIIPRSSWLAQKPMDEPLPLQLPVKYVVILHTATESSEKRAINVRLIRDMQCFHIESRGWNDIAYNFLVGCDGNIYEGRGWKTVGAHTLGYNRISLGISFIGCFMKELPTADALNMCRNLLARGVEDGHISTDYRLICHCQCNSTESPGRRLYEEIQTWPHFYNIEEEEQ
Sequence Length
345
Species
Drosophila melanogaster (Fruit fly)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
39,426 Da
NCBI Official Full Name
peptidoglycan recognition protein LE, isoform B
NCBI Official Synonym Full Names
Peptidoglycan recognition protein LE
NCBI Official Symbol
PGRP-LE
NCBI Official Synonym Symbols
anon-WO0153538.66; CG8995; DmelCG8995; PGRP; pgrp le; pgrp-le
NCBI Protein Information
CG8995 gene product from transcript CG8995-RB
UniProt Protein Name
Peptidoglycan-recognition protein LE
Protein Family
UniProt Gene Name
PGRP-LE
Uniprot Description
Peptidoglycan-recognition protein that plays a key role in innate immnunity by binding to murein peptidoglycans (PGN) of Gram-negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is required for infection-dependent activation of melanization. Required for Relish processing and nuclear translocation following proteolytic cleavage. Its localization suggests a role in the recognition and subsequent activation of the signaling at the first point of contact with invading bacteria.
Research Articles on PGRP-LE
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Product Notes
The PGRP-LE pgrp-le (Catalog #AAA1303344) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-345, Full length protein. The amino acid sequence is listed below: MSESGIKKLS QERTREWLAS QEDEELESIA ESSVVDSLDY DYTEEEEDAD QNTSEEISTM TLGTQIATKK HSIISDTIRD LMNSINSIQT LGNVNISNST NVHIGNVTNI NGNIQIIADG LTQNRRDRRH VSPPRDNAPK TPTHFEDDYQ DESEERVRSD VFIRRQKFKI PKELSAIIPR SSWLAQKPMD EPLPLQLPVK YVVILHTATE SSEKRAINVR LIRDMQCFHI ESRGWNDIAY NFLVGCDGNI YEGRGWKTVG AHTLGYNRIS LGISFIGCFM KELPTADALN MCRNLLARGV EDGHISTDYR LICHCQCNST ESPGRRLYEE IQTWPHFYNI EEEEQ. It is sometimes possible for the material contained within the vial of "Peptidoglycan-recognition protein LE (PGRP-LE), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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