Autophagy protein 5 (Atg5) Recombinant Protein | Atg5 recombinant protein

Recombinant Mouse Autophagy protein 5 (Atg5)

Cat. Num. AAA1283004

• Gene Names: Atg5; Apg5l; Atg5l; Paddy; C88337; AW319544; 2010107M05Rik; 3110067M24Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Autophagy protein 5 (Atg5); Recombinant Mouse Autophagy protein 5 (Atg5); Atg5 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-275, full length protein
• Sequence: MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDVSEIWFEYEGTPLKWHYPIGLLFDLLASSSALPWNITVHFKSFPEKDLLHCPSKDAVEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNDRFDQFWAINRKLMEYPPEENGFRYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLGDLLREVCPSAVAPEDGEKRSQVMIHGIEPMLETPLQWLSEHLSYPDNFLHISIVPQPTD
• Sequence Length: 275

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 930155595
• NCBI GeneID: 11793
• NCBI Accession #: NP_001300942.1
• NCBI GenBank Nucleotide #: NM_001314013.1
• UniProt Accession #: Q99J83
• Molecular Weight: 32,402 Da
• NCBI Official Full Name: autophagy protein 5 isoform 2
• NCBI Official Synonym Full Names: autophagy related 5
• NCBI Official Symbol: Atg5
• NCBI Official Synonym Symbols: Apg5l; Atg5l; Paddy; C88337; AW319544; 2010107M05Rik; 3110067M24Rik
• NCBI Protein Information: autophagy protein 5
• UniProt Protein Name: Autophagy protein 5
• Protein Family: Autophagy protein
• UniProt Gene Name: Atg5
• UniProt Synonym Gene Names: Apg5l

NCBI Description

The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Uniprot Description

Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.