Complement regulatory protein Crry (Crry) Recombinant Protein | Crry recombinant protein

Recombinant Rat Complement regulatory protein Crry (Crry), partial

Cat. Num. AAA1280583

• Gene Names: Cr1l; Cr1; Crry
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Complement regulatory protein Crry (Crry); Recombinant Rat Complement regulatory protein Crry (Crry); partial; Crry recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 36-482
• Sequence: GQCPA PPLFPYAKPI NPTDESTFPV GTSLKYECRP GYIKRQFSIT CEVNSVWTSP QDVCIRKQCE TPLDPQNGIV HVNTDIRFGS SITYTCNEGY RLIGSSSAMC IISDQSVAWD AEAPICESIP CEIPPSIPNG DFFSPNREDF HYGMVVTYQC NTDARGKKLF NLVGEPSIHC TSIDGQVGVW SGPPPQCIEL NKCTPPHVEN AVIVSKNKSL FSLRDMVEFR CQDGFMMKGD SSVYCRSLNR WEPQLPSCFK VKSCGAFLGE LPNGHVFVPQ NLQLGAKVTF VCNTGYQLKG NSSSHCVLDG VESIWNSSVP VCEQVICKLP QDMSGFQKGL QMKKDYYYGD NVALECEDGY TLEGSSQSQC QSDASWDPPL PKCVSQVICK LPQDMSGFQK GLQMKKDYYY GDNVALECED GYTLEGSSQS QCQSDASWDP PLPKCVSRSN SG
• Sequence Length: 447

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 53759105
• NCBI GeneID: 54243
• NCBI Accession #: NP_001005265.1
• NCBI GenBank Nucleotide #: NM_001005265.1
• UniProt Accession #: Q63135; Q63612
• Molecular Weight: 54,787 Da
• NCBI Official Full Name: complement component receptor 1-like protein isoform 3
• NCBI Official Synonym Full Names: complement C3b/C4b receptor 1 like
• NCBI Official Symbol: Cr1l
• NCBI Official Synonym Symbols: Cr1; Crry
• NCBI Protein Information: complement component receptor 1-like protein
• UniProt Protein Name: Complement component receptor 1-like protein
• UniProt Gene Name: Cr1l
• UniProt Synonym Gene Names: Crry

NCBI Description

This gene encodes a membrane-bound inhibitor of complement activation, which contains several tandemly arranged short consensus repeats (SCRs) of approximately 60 amino acids. The encoded protein may play a role in tumor immune surveillance, which is unrelated to complement inhibition. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance.