SNX18 cdna clone
SNX18 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
SNX18: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: clathrin-coated vesicle; cytoplasmic membrane-bound vesicle; endosome; extrinsic to internal side of plasma membrane; intracellular membrane-bound organelle; nucleoplasm
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding
Biological Process: cytokinesis after mitosis; endocytosis; endosome transport; positive regulation of GTPase activity; vesicle organization and biogenesis
Research Articles on SNX18
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Product Notes
The SNX18 snx18 (Catalog #AAA1278907) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCGCTGC GCGCCCGGGC GCTGTACGAC TTCAGGTCGG AGAACCCAGG AGAGATCTCG CTGCGAGAGC ACGAGGTGCT GAGCCTGTGC AGCGAGCAGG ACATCGAGGG CTGGCTCGAG GGGGTCAACA GCCGCGGCGA CCGCGGCCTC TTCCCGGCCT CCTATGTGCA GGTGATCCGC GCCCCCGAGC CTGGCCCGGC GGGAGACGGC GGCCCGGGCG CCCCGGCCCG CTACGCCAAT GTGCCCCCCG GGGGCTTCGA GCCCCTGCCC GTCGCGCCCC CCGCCTCCTT CAAGCCGCCG CCTGACGCCT TCCAGGCGCT GCTGCAGCCA CAGCAGGCGC CGCCTCCGAG CACCTTCCAG CCGCCCGGCG CGGGCTTCCC GTACGGCGGG GGCGCCCTGC AGCCGTCGCC TCAGCAGCTC TACGGCGGCT ACCAGGCCAG CCAAGGCAGC GATGATGACT GGGACGACGA GTGGGACGAC AGCTCCACGG TGGCGGACGA GCCGGGCGCT CTGGGCAGCG GAGCATACCC GGACCTCGAC GGCTCGTCTT CGGCGGGTGT GGGCGCAGCC GGCCGCTACC GCCTGTCCAC GCGCTCCGAC CTGTCCCTGG GCTCCCGCGG CGGCTCGGTC CCCCCGCAGC ACCACCCGTC GGGGCCCAAG AGCTCGGCCA CCGTGAGCCG CAACCTCAAT CGCTTCTCCA CCTTCGTCAA GTCCGGCGGG GAGGCCTTCG TGCTGGGGGA GGCGTCAGGC TTCGTGAAGG ACGGGGACAA GCTGTGCGTG GTGCTGGGGC CCTATGGCCC CGAGTGGCAG GAGAACCCCT ACCCGTTCCA GTGCACCATC GACGACCCCA CCAAGCAGAC CAAGTTCAAG GGCATGAAGA GCTACATCTC CTACAAGCTG GTGCCCACGC ACACGCAGGT GCCGGTGCAT CGGCGCTACA AGCACTTCGA CTGGCTGTAC GCGCGCCTGG CGGAGAAGTT CCCGGTCATC TCCGTGCCCC ACCTGCCCGA GAAGCAGGCC ACCGGCCGCT TCGAGGAGGA CTTCATCTCT AAGCGCAGGA AGGGCCTGAT CTGGTGGATG AACCACATGG CCAGCCACCC AGTGCTGGCG CAGTGCGACG TCTTCCAGCA CTTCCTGACG TGCCCCAGCA GCACCGACGA GAAAGCCTGG AAGCAGGGCA AGAGGAAGGC CGAGAAGGAC GAGATGGTGG GCGCCAACTT CTTCCTGACC CTTAGCACGC CCCCCGCCGC TGCCCTTGAC CTGCAGGAGG TGGAGAGCAA GATCGACGGC TTCAAGTGCT TCACCAAGAA GATGGACGAC AGCGCGCTGC AGCTCAACCA CACGGCCAAC GAGTTCGCGC GCAAGCAGGT GACCGGCTTC AAAAAGGAGT ATCAGAAGGT GGGCCAGTCC TTCCGCGGCC TCAGCCAGGC CTTTGAGCTG GACCAGCAGG CCTTCTCGGT GGGCCTGAAC CAGGCTATCG CCTTCACCGG AGATGCCTAT GACGCCATTG GCGAGCTCTT CGCGGAGCAG CCCAGGCAGG ACCTGGATCC CGTCATGGAC CTATTAGCGC TGTATCAGGG GCATCTGGCT AACTTCCCGG ACATCATCCA CGTTCAGAAA GGAGCTCTTA CCAAAGTCAA GGAGAGTAGG CGACACGTGG AGGAAGGGAA GATGGAGGTG CAGAAGGCTG ACGGCATTCA GGATCGCTGT AACACTATTT CTTTTGCCAC TTTGGCTGAA ATTCACCACT TCCATCAAAT TCGAGTGAGA GACTTTAAAT CACAGATGCA GCATTTCTTA CAACAACAAA TAATATTTTT CCAAAAAGTT ACCCAGAAGT TGGAAGAAGC TCTTCACAAA TATGATAGTG TTTAA. It is sometimes possible for the material contained within the vial of "SNX18, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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