UBQLN1 cdna clone
UBQLN1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
UBQLN1: Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors. Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 9q22|9q21.2-q21.3
Cellular Component: nucleoplasm; proteasome complex; protein complex; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm
Molecular Function: protein domain specific binding; protein binding; kinase binding
Biological Process: regulation of protein ubiquitination
Research Articles on UBQLN1
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Product Notes
The UBQLN1 ubqln1 (Catalog #AAA1278421) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccgaga gtggtgaaag cggcggtcct ccgggctccc aggatagcgc cgccggagcc gaaggtgctg gcgcccccgc ggccgctgcc tccgcggagc ccaaaatcat gaaagtcacc gtgaagaccc cgaaggaaaa ggaggaattc gccgtgcccg agaatagctc cgtccagcag tttaaggaag aaatctctaa acgttttaaa tcacatactg accaacttgt gttgatattt gctggaaaaa ttttgaaaga tcaagatacc ttgagtcagc atggaattca tgatggactt actgttcacc ttgtcattaa aacacaaaac aggcctcagg atcattcagc tcagcaaaca aatacagctg gaagcaatgt tactacatca tcaactccta atagtaactc tacatctggt tctgctacta gcaacccttt tggtttaggt ggccttgggg gacttgcagg tctgagtagc ttgggtttga atactaccaa cttctctgaa ctacagagtc agatgcagcg acaacttttg tctaaccctg aaatgatggt ccagatcatg gaaaatccct ttgttcagag catgctctca aatcctgacc tgatgagaca gttaattatg gccaatccac aaatgcagca gttgatacag agaaatccag aaattagtca tatgttgaat aatccagata taatgagaca aacgttggaa cttgccagga atccagcaat gatgcaggag atgatgagga accaggaccg agctttgagc aacctagaaa gcatcccagg gggatataat gctttaaggc gcatgtacac agatattcag gaaccaatgc tgagtgctgc acaagagcag tttggtggta atccatttgc ttccttggtg agcaatacat cctctggtga aggtagtcaa ccttcccgta cagaaaatag agatccacta cccaatccat gggctccaca gacttcccag agttcatcag cttccagcgg cactgccagc actgtgggtg gcactactgg tagtactgcc agtggcactt ctgggcagag tactactgcg ccaaatttgg tgcctggagt aggagctagt atgttcaaca caccaggaat gcagagcttg ttgcaacaaa taactgaaaa cccacaactg atgcaaaaca tgttgtctgc cccctacatg agaagcatga tgcagtcact aagccagaat cctgaccttg ctgcacagat gcagaatcct gatacactat cagcaatgtc aaaccctaga gcaatgcagg ccttgttaca gattcagcag ggtttacaga cattagcaac ggaagccccg ggcctcatcc cagggtttac tcctggcttg ggggcattag gaagcactgg aggctcttcg ggaactaatg gatctaacgc cacacctagt gaaaacacaa gtcccacagc aggaaccact gaacctggac atcagcagtt tattcagcag atgctgcagg ctcttgctgg agtaaatcct cagctacaga atccagaagt cagatttcag caacaactgg aacaactcag tgcaatggga tttttgaacc gtgaagcaaa cttgcaagct ctaatagcaa caggaggtga tatcaatgca gctattgaaa ggttactggg ctcccagcca tcatag. It is sometimes possible for the material contained within the vial of "UBQLN1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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