GABARAP cdna clone
GABARAP cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
Uniprot Description
GABARAP: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Belongs to the MAP1 LC3 family. Interacts with GPHN and NSF. Interacts with GABRG2, beta-tubulin and ULK1.
Protein type: Adaptor/scaffold; Vesicle; Ubiquitin-like modifier; Microtubule-binding; Autophagy
Chromosomal Location of Human Ortholog: 17p13.1
Research Articles on GABARAP
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Product Notes
The GABARAP gabarap (Catalog #AAA1278119) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAAGTTCG TGTACAAAGA AGAGCATCCG TTCGAGAAGC GCCGCTCTGA GGGCGAGAAG ATCCGAAAGA AATACCCGGA CCGGGTGCCG GTGATAGTAG AAAAGGCTCC CAAAGCTCGG ATAGGAGACC TGGACAAAAA GAAATACCTG GTGCCTTCTG ATCTCACAGT TGGTCAGTTC TACTTCTTGA TCCGGAAGCG AATTCATCTC CGAGCTGAGG ATGCCTTGTT TTTCTTTGTC AACAATGTCA TTCCACCCAC CAGTGCCACA ATGGGTCAGC TGTACCAGGA ACACCATGAA GAAGACTTCT TTCTCTACAT TGCCTACAGT GACGAAAGTG TCTACGGTCT GTGA. It is sometimes possible for the material contained within the vial of "GABARAP, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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