BIRC5 cdna clone
BIRC5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Uniprot Description
Survivin: an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: chromosome, pericentric region; cytoplasm; cytosol; midbody; nuclear chromosome; nucleoplasm; nucleus
Molecular Function: chaperone binding; enzyme binding; identical protein binding; microtubule binding; protein binding; Ran GTPase binding; ubiquitin-protein ligase activity
Biological Process: negative regulation of apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; protein amino acid phosphorylation; protein complex localization; protein sumoylation; regulation of apoptosis; regulation of signal transduction; sister chromatid cohesion
Research Articles on BIRC5
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Product Notes
The BIRC5 birc5 (Catalog #AAA1278111) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggtgccc cgacgttgcc ccctgcctgg cagccctttc tcaaggacca ccgcatctct acattcaaga actggccctt cttggagggc tgcgcctgca ccccggagcg gatggccgag gctggcttca tccactgccc cactgagaac gagccagact tggcccagtg tttcttctgc ttcaaggagc tggaaggctg ggagccagat gacgacccca tagaggaaca taaaaagcat tcgtccggtt gcgctttcct ttctgtcaag aagcagtttg aagaattaac ccttggtgaa tttttgaaac tggacagaga aagagccaag aacaaaattg caaaggaaac caacaataag aagaaagaat ttgaggaaac tgcgaagaaa gtgcgccgtg ccatcgagca gctggctgcc atggattga. It is sometimes possible for the material contained within the vial of "BIRC5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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