DAZ1 cdna clone
DAZ1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains. [provided by RefSeq, Jul 2008]
Uniprot Description
DAZ1: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells. Defects in DAZ1 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2). It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility. Belongs to the RRM DAZ family.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: Yq11.223
Molecular Function: protein binding; translation activator activity
Biological Process: positive regulation of translational initiation
Disease: Spermatogenic Failure, Y-linked, 2
Research Articles on DAZ1
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Product Notes
The DAZ1 daz1 (Catalog #AAA1277979) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT GTAACTCAGC ACGTTCAGTC TGCTGCAAAT CCTGAGACTC CAAACTCAAC CATCTCCAGA GAGGCCAGCA CCCAGTCTTC ATCAGCTGCA GCTAGCCAAG GCTGGGTGTT ACCAGAAGGC AAAATCGTGC CAAACACTGT TTTTGTTGGT GGAATTGATG CTAGGATGGA TGAAACTGAG ATTGGAAGCT GCTTTGGTAG ATACGGTTCA GTGAAAGAAG TGAAGATAAT CACGAATCGA ACTGGTGTGT CCAAAGGCTA TGGATTTGTT TCGTTTGTTA ATGACGTGGA TGTCCAGAAG ATAGTAGGAT CACAGATACA TTTCCATGGT AAAAAGCTGA AGCTGGGCCC TGCAATCAGG AAACAAAAGT TATGTGCTCG TCATGTGCAG CCACGTCCTT TGGTAGTTAA TCCTCCTCCT CCACCACAGT TTCAGAACGT CTGGCGGAAT CCAAACACTG AAACCTACCT GCAGCCCCAA ATCACGCCGA ATCCTGTAAC TCAGCACGTT CAGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT GTAACTCAGC ACGTTCAGGC TTACTCTGCT TATCCACATT CACCAGGTCA GGTCATCACT GGATGTCAGT TGCTTGTATA TAATTATCAG GAATATCCTA CTTATCCCGA TTCAGCATTT CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGCCATTTCC TGCTTATCCA AGATCACCAT TTCAGGTCAC TGCTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT CCTGCTTATC CAAATTCACC ATTTCAAGTC GCCACTGGAT ATCAGTTCCC TGTATGTGAA ATTTGCAAAA TACTGGTATT AAAGAACGCT GCAGCTTTTT TATGTCACTC AAAGGTTAAT CGGAGTATCT GA. It is sometimes possible for the material contained within the vial of "DAZ1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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