SFTPB cdna clone
SFTPB cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]
Uniprot Description
SFTPB: Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1); also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid- Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS). RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2p12-p11.2
Cellular Component: clathrin-coated endocytic vesicle; endoplasmic reticulum membrane; extracellular region; extracellular space; lamellar body; multivesicular body; nucleoplasm
Molecular Function: enzyme activator activity; G-protein-coupled receptor binding
Biological Process: cellular protein metabolic process; organ morphogenesis
Disease: Surfactant Metabolism Dysfunction, Pulmonary, 1
Research Articles on SFTPB
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Product Notes
The SFTPB sftpb (Catalog #AAA1277670) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctgagt cacacctgct gcagtggctg ctgctgctgc tgcccacgct ctgtggccca ggcactgctg cctggaccac ctcatccttg gcctgtgccc agggccctga gttctggtgc caaagcctgg agcaagcatt gcagtgcaga gccctagggc attgcctaca ggaagtctgg ggacatgtgg gagccgatga cctatgccaa gagtgtgagg acatcgtcca catccttaac aagatggcca aggaggccat tttccaggac acgatgagga agttcctgga gcaggagtgc aacgtcctcc ccttgaagct gctcatgccc cagtgcaacc aagtgcttga cgactacttc cccctggtca tcgactactt ccagaaccag actgactcaa acggcatctg tatgcacctg ggcctgtgca aatcccggca gccagagcca gagcaggagc cagggatgtc agaccccctg cccaaacctc tgcgggaccc tctgccagac cctctgctgg acaagctcgt cctccctgtg ctgcccgggg ccctccaggc gaggcctggg cctcacacac aggatctctc cgagcagcaa ttccccattc ctctccccta ttgctggctc tgcagggctc tgatcaagcg gatccaagcc atgattccca agggtgcgct agctgtggca gtggcccagg tgtgccgcgt ggtacctctg gtggcgggcg gcatctgcca gtgcctggct gagcgctact ccgtcatcct gctcgacacg ctgctgggcc gcatgctgcc ccagctggtc tgccgcctcg tcctccggtg ctccatggat gacagcgctg gcccaaggtc gccgacagga gaatggctgc cgcgagactc tgagtgccac ctctgcatgt ccgtgaccac ccaggccggg aacagcagcg agcaggccat accacaggca atgctccagg cctgtgttgg ctcctggctg gacagggaaa agtgcaagca atttgtggag cagcacacgc cccagctgct gaccctggtg cccaggggct gggatgccca caccacctgc caggccctcg gggtgtgtgg gaccatgtcc agccctctcc agtgtatcca cagccccgac ctttga. It is sometimes possible for the material contained within the vial of "SFTPB, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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