THRA cdna clone
THRA cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
TR-alpha: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Interacts with SRC-3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Four splice variant isoforms have been described.
Protein type: Transcription factor; Nuclear receptor; DNA-binding
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cytosol; nucleoplasm; nucleus
Molecular Function: protein binding; protein domain specific binding; TATA-binding protein binding; thyroid hormone receptor activity; transcription factor activity; transcription factor binding
Biological Process: hormone-mediated signaling; negative regulation of transcription, DNA-dependent; negative regulation of transcriptional preinitiation complex assembly; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
Disease: Hypothyroidism, Congenital, Nongoitrous, 6
Research Articles on THRA
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Product Notes
The THRA thra (Catalog #AAA1277464) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggaacaga agccaagcaa ggtggagtgt gggtcagacc cagaggagaa cagtgccagg tcaccagatg gaaagcgaaa aagaaagaac ggccaatgtt ccctgaaaac cagcatgtca gggtatatcc ctagttacct ggacaaagac gagcagtgtg tcgtgtgtgg ggacaaggca actggttatc actaccgctg tatcacttgt gagggctgca agggcttctt tcgccgcaca atccagaaga acctccatcc cacctattcc tgcaaatatg acagctgctg tgtcattgac aagatcaccc gcaatcagtg ccagctgtgc cgcttcaaga agtgcatcgc cgtgggcatg gccatggact tggttctaga tgactcgaag cgggtggcca agcgtaagct gattgagcag aaccgggagc ggcggcggaa ggaggagatg atccgatcac tgcagcagcg accagagccc actcctgaag agtgggatct gatccacatt gccacagagg cccatcgcag caccaatgcc cagggcagcc attggaaaca gaggcggaaa ttcctgcccg atgacattgg ccagtcaccc attgtctcca tgccggacgg agacaaggtg gacctggaag ccttcagcga gtttaccaag atcatcaccc cggccatcac ccgtgtggtg gactttgcca aaaaactgcc catgttctcc gagctgcctt gcgaagacca gatcatcctc ctgaaggggt gctgcatgga gatcatgtcc ctgcgggcgg ctgtccgcta cgaccctgag agcgacaccc tgacgctgag tggggagatg gctgtcaagc gggagcagct caagaatggc ggcctgggcg tagtctccga cgccatcttt gaactgggca agtcactctc tgcctttaac ctggatgaca cggaagtggc tctgctgcag gctgtgctgc taatgtcaac agaccgctcg ggcctgctgt gtgtggacaa gatcgagaag agtcaggagg cgtacctgct ggcgttcgag cactacgtca accaccgcaa acacaacatt ccgcacttct ggcccaagct gctgatgaag gagagagaag tgcagagttc gattctgtac aagggggcag cggcagaagg ccggccgggc gggtcactgg gcgtccaccc ggaaggacag cagcttctcg gaatgcatgt tgttcagggt ccgcaggtcc ggcagcttga gcagcagctt ggtgaagcgg gaagtctcca agggccggtt cttcagcacc agagcccgaa gagcccgcag cagcgtctcc tggagctgct ccaccgaagc ggaattctcc atgcccgagc ggtctgtggg gaagacgaca gcagtgaggc ggactccccg agctcctctg aggaggaacc ggaggtctgc gaggacctgg caggcaatgc agcctctccc tga. It is sometimes possible for the material contained within the vial of "THRA, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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