ASB4 cdna clone
ASB4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]
Uniprot Description
ASB4: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 7q21-q22
Cellular Component: Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; cytoplasm; nucleus
Molecular Function: ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Research Articles on ASB4
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Product Notes
The ASB4 asb4 (Catalog #AAA1277248) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGACGGCA CCACTGCCCC TGTCACTAAA TCTGGAGCTG CCAAGTTAGT TAAGAGAAAT TTCCTTGAGG CGCTAAAGTC CAATGACTTC GGAAAATTGA AGGCTATTTT GATCCAAAGG CAAATAGATG TGGACACTGT TTTTGAAGTC GAAGATGAGA ATATGGTTTT GGCATCTTAT AAACAAGGTT ACTGGTTGCC TAGCTATAAA TTGAAGTCTT CCTGGGCCAC AGGCCTCCAT CTCTCTGTCT TGTTTGGCCA TGTGGAATGT CTTCTGGTGC TACTGGACCA CAATGCTACA ATCAACTGTA GACCCAATGG GAAAACCCCT CTTCACGTGG CTTGTGAAAT GGCCAATGTG GATTGTGTTA AGATCCTCTG TGATCGTGGG GCAAAGCTCA ATTGCTACTC CTTAAGTGGA CACACAGCTT TGCACTTTTG TACAACTCCA AGTTCCATTC TCTGTGCCAA GCAATTGGTT TGGAGAGGGG CGAATGTGAA CATGAAGACC AACAACCAAG ATGAGGAGAC GCCCTTGCAC ACGGCTGCCC ACTTCGGCCT TTCGGAGCTG GTGGCCTTCT ACGTGGAACA CGGGGCCATA GTGGACAGCG TGAATGCCCA CATGGAGACC CCCCTGGCCA TCGCCGCCTA CTGGGCCCTC CGCTTTAAGG AGCAGGAGTA CAGCACGGAG CACCACCTGG TCTGCCGCAT GCTGCTTGAC TACAAAGCCG AAGTCAATGC CCGAGATGAC GACTTTAAAT CTCCCCTCCA CAAGGCAGCC TGGAACTGTG ACCACGTGCT CATGCACATG ATGCTGGAAG CTGGCGCCGA AGCCAATCTC ATGGATATCA ACGGCTGTGC TGCCATCCAG TACGTGCTGA AGGTCACCTC CGTGCGCCCT GCTGCCCAGC CTGAGATCTG CTACCAGCTC CTGTTGAACC ATGGGGCTGC CCGAATATAC CCTCCACAGT TCCATAAGGT GAGGCTCTGC CCAGTGGTCA GCAGGTTGAG GAAGATTCAA ATGGCAGCCT TGTCTGAAAT CTCCAAGTAA. It is sometimes possible for the material contained within the vial of "ASB4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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