CYP2C9 cdna clone
CYP2C9 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
Uniprot Description
CYP2C9: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan. Belongs to the cytochrome P450 family.
Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Secondary Metabolites Metabolism - limonene and pinene degradation; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.14.14.1; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - linoleic acid
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle
Molecular Function: arachidonic acid epoxygenase activity; drug binding; monooxygenase activity; oxidoreductase activity; oxygen binding; steroid hydroxylase activity
Biological Process: amide metabolic process; drug catabolic process; drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; monocarboxylic acid metabolic process; monoterpenoid metabolic process; steroid metabolic process; urea metabolic process; xenobiotic metabolic process
Disease: Coumarin Resistance
Research Articles on CYP2C9
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Product Notes
The CYP2C9 cyp2c9 (Catalog #AAA1277232) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGATTCTC TTGTGGTCCT TGTGCTCTGT CTCTCATGTT TGCTTCTCCT TTCACTCTGG AGACAGAGCT CTGGGAGAGG AAAACTCCCT CCTGGCCCCA CTCCTCTCCC AGTGATTGGA AATATCCTAC AGATAGGTAT TAAGGACATC AGCAAATCCT TAACCAATCT CTCAAAGGTC TATGGCCCTG TGTTCACTCT GTATTTTGGC CTGAAACCCA TAGTGGTGCT GCATGGATAT GAAGCAGTGA AGGAAGCCCT GATTGATCTT GGAGAGGAGT TTTCTGGAAG AGGCATTTTC CCACTGGCTG AAAGAGCTAA CAGAGGATTT GGAATTGTTT TCAGCAATGG AAAGAAATGG AAGGAGATCC GGCGTTTCTC CCTCATGACG CTGCGGAATT TTGGGATGGG GAAGAGGAGC ATTGAGGACC GTGTTCAAGA GGAAGCCCGC TGCCTTGTGG AGGAGTTGAG AAAAACCAAG GCCTCACCCT GTGATCCCAC TTTCATCCTG GGCTGTGCTC CCTGCAATGT GATCTGCTCC ATTATTTTCC ATAAACGTTT TGATTATAAA GATCAGCAAT TTCTTAACTT AATGGAAAAG TTGAATGAAA ACATCAAGAT TTTGAGCAGC CCCTGGATCC AGATCTGCAA TAATTTTTCT CCTATCATTG ATTACTTCCC GGGAACTCAC AACAAATTAC TTAAAAACGT TGCTTTTATG AAAAGTTATA TTTTGGAAAA AGTAAAAGAA CACCAAGAAT CAATGGACAT GAACAACCCT CAGGACTTTA TTGATTGCTT CCTGATGAAA ATGGAGAAGG AAAAGCACAA CCAACCATCT GAATTTACTA TTGAAAGCTT GGAAAACACT GCAGTTGACT TGTTTGGAGC TGGGACAGAG ACGACAAGCA CAACCCTGAG ATATGCTCTC CTTCTCCTGC TGAAGCACCC AGAGGTCACA GCTAAAGTCC AGGAAGAGAT TGAACGTGTG ATTGGCAGAA ACCGGAGCCC CTGCATGCAA GACAGGAGCC ACATGCCCTA CACAGATGCT GTGGTGCACG AGGTCCAGAG ATACATTGAC CTTCTCCCCA CCAGCCTGCC CCATGCAGTG ACCTGTGACA TTAAATTCAG AAACTATCTC ATTCCCAAGG GCACAACCAT ATTAATTTCC CTGACTTCTG TGCTACATGA CAACAAAGAA TTTCCCAACC CAGAGATGTT TGACCCTCAT CACTTTCTGG ATGAAGGTGG CAATTTTAAG AAAAGTAAAT ACTTCATGCC TTTCTCAGCA GGAAAACGGA TTTGTGTGGG AGAAGCCCTG GCCGGCATGG AGCTGTTTTT ATTCCTGACC TCCATTTTAC AGAACTTTAA CCTGAAATCT CTGGTTGACC CAAAGAACCT TGACACCACT CCAGTTGTCA ATGGATTTGC CTCTGTGCCG CCCTTCTACC AGCTGTGCTT CATTCCTGTC TGA. It is sometimes possible for the material contained within the vial of "CYP2C9, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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