SPACA3 cdna clone
SPACA3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Description
SPACA3: a single-pass type II sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Expressed in testis, epididymis and placenta. Although it belongs to the glycosyl hydrolase 22 family, T122 and N139 are present instead of the conserved Glu and Asp which are active site residues. It is therefore expected that this protein lacks hydrolase activity. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from RefSeq and UniProtKB
Protein type: Membrane protein, integral; Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: extracellular region; lysosome; secretory granule
Molecular Function: lysozyme activity; protein binding
Biological Process: cell wall catabolic process; defense response to Gram-positive bacterium; monocyte activation; peptidoglycan catabolic process; positive regulation of macrophage activation; positive regulation of phagocytosis; response to virus
Research Articles on SPACA3
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Product Notes
The SPACA3 spaca3 (Catalog #AAA1276780) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGACTTCGG GCTGGACGGA TACCGGGGAT ACAGCCTGGC TGACTGCCTA TGCTCTGCCC TATGCAGGGG TCTGCCTTGC TTATTTCACA AGCGGTTTCA ACGCAGCTGC TTTGGACTAC GAGGCTGATG GGAGCACCAA CAACGGGATC TTCCAGATCA ACAGCCGGAG GTGGTGCAGC AACCTCACCC CGAACGTCCC CAACGTGTGC CGGATGTACT GCTCAGATTT GTTGAATCCT AATCTCAAGG ATACCGTTAT CTGTGCCATG AAGATAACCC AAGAGCCTCA GGGTCTGGGT TACTGGGAGG CCTGGAGGCA TCACTGCCAG GGAAAAGACC TCACTGAATG GGTGGATGGC TGTGACTTCT AG. It is sometimes possible for the material contained within the vial of "SPACA3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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