PVRL4 cdna clone
PVRL4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
Uniprot Description
nectin 4: Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells. Defects in PVRL4 are the cause of ectodermal dysplasia- syndactyly syndrome type 1 (EDSS1). EDSS1 is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating. Belongs to the nectin family.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: cell-cell adherens junction; integral to plasma membrane; intercellular junction; plasma membrane
Molecular Function: cell adhesion molecule binding; protein binding; protein homodimerization activity; receptor activity; receptor binding
Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion
Disease: Ectodermal Dysplasia-syndactyly Syndrome 1
Research Articles on PVRL4
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Product Notes
The PVRL4 nectin4 (Catalog #AAA1275974) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcccctgt ccctgggagc cgagatgtgg gggcctgagg cctggctgct gctgctgcta ctgctggcat catttacagg ccggtgcccc gcgggtgagc tggagacctc agacgtggta actgtggtgc tgggccagga cgcaaaactg ccctgcttct accgagggga ctccggcgag caagtggggc aagtggcatg ggctcgggtg gacgcgggcg aaggcgccca ggaactagcg ctactgcact ccaaatacgg gcttcatgtg agcccggctt acgagggccg cgtggagcag ccgccgcccc cacgcaaccc cctggacggc tcagtgctcc tgcgcaacgc agtgcaggcg gatgagggcg agtacgagtg ccgggtcagc accttccccg ccggcagctt ccaggcgcgg ctgcggctcc gagtgctggt gcctcccctg ccctcactga atcctggtcc agcactagaa gagggccagg gcctgaccct ggcagcctcc tgcacagctg agggcagccc agcccccagc gtgacctggg acacggaggt caaaggcaca acgtccagcc gttccttcaa gcactcccgc tctgctgccg tcacctcaga gttccacttg gtgcctagcc gcagcatgaa tgggcagcca ctgacttgtg tggtgtccca tcctggcctg ctccaggacc aaaggatcac ccacatcctc cacgtgtcct tccttgctga ggcctctgtg aggggccttg aagaccaaaa tctgtggcac attggcagag aaggagctat gctcaagtgc ctgagtgaag ggcagccccc tccctcatac aactggacac ggctggatgg gcctctgccc agtggggtac gagtggatgg ggacactttg ggctttcccc cactgaccac tgagcacagc ggcatctacg tctgccatgt cagcaatgag ttctcctcaa gggattctca ggtcactgtg gatgttcttg acccccagga agactctggg aagcaggtgg acctagtgtc agcctcggtg gtggtggtgg gtgtgatcgc cgcactcttg ttctgccttc tggtggtggt ggtggtgctc atgtcccgat accatcggcg caaggcccag cagatgaccc agaaatatga ggaggagctg accctgacca gggagaactc catccggagg ctgcattccc atcacacgga ccccaggagc cagccggagg agagtgtagg gctgagagcc gagggccacc ctgatagtct caaggacaac agtagctgct ctgtgatgag tgaagagccc gagggccgca gttactccac gctgaccacg gtgagggaga tagaaacaca gactgaactg ctgtctccag gctctgggcg ggccgaggag gaggaagatc aggatgaagg catcaaacag gccatgaacc attttgttca ggagaatggg accctacggg ccaagcccac gggcaatggc atctacatca atgggcgggg acacctggtc tga. It is sometimes possible for the material contained within the vial of "PVRL4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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