EED cdna clone
EED cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
EED: a member of the superfamily of Polycomb group (PcG) methyltransferase proteins with WD-40 repeats. PcG complexes mediate chromatin modifications that contribute to transcriptional silencing during development and carcinogenesis. A part of the Polycomb-repressive complex 2 (PRC2) along with EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. Interacts with HDAC, HDAC2, histone H1 and YY1. PRC2 trimethylates histone H3 on K9 and K27, transcriptionally repressing target gene including HOXC8, HOXA9, MYT1 and CDKN2A. Appears to be overexpressed in breast and colon cancers. Inhibitors of PRC2-mediated gene repression are being investigated as a cancer therapy. EED and EZH2 are also implicated in the silencing of the inactive X chromosome. Three human isoforms produced by alternative splicing or initiation have been described, and additional isoforms may be produced by alternative initiation.
Protein type: Methyltransferase
Chromosomal Location of Human Ortholog: 11q14.2-q22.3
Cellular Component: ESC/E(Z) complex; nucleolus; nucleoplasm; nucleus
Molecular Function: histone methyltransferase activity; identical protein binding; protein binding
Biological Process: negative regulation of gene expression, epigenetic
Research Articles on EED
Similar Products
Product Notes
The EED eed (Catalog #AAA1275591) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtccgaga gggaagtgtc gactgcgccg gcgggaacag acatgcctgc ggccaagaag cagaagctga gcagtgacga gaacagcaat ccagacctct ctggagacga gaatgatgac gctgtcagta tagaaagtgg tacaaacact gaacgccctg atacacctac aaacacgcca aatgcacctg gaaggaaaag ttggggaaag ggaaaatgga agtcaaagaa atgcaaatat tctttcaaat gtgtaaatag tctcaaggaa gatcataacc aaccattgtt tggagttcag tttaactggc acagtaaaga aggagatcca ttagtgtttg caactgtagg aagcaacaga gttaccttgt atgaatgtca ttcacaagga gaaatccggt tgttgcaatc ttacgtggat gctgatgctg atgaaaactt ttacacttgt gcatggacct atgatagcaa tacgagccat cctctgctgg ctgtagctgg atctagaggc ataattagga taataaatcc tataacaatg cagtgtataa agcactatgt tggccatgga aatgctatca atgagctgaa attccatcca agagatccaa atcttctcct gtcagtaagt aaagatcatg ctttacgatt atggaatatc cagacggaca ctctggtggc aatatttgga ggcgtagaag ggcacagaga tgaagttcta agtgctgatt atgatctttt gggtgaaaaa ataatgtcct gtggtatgga tcattctctt aaactttgga ggatcaattc aaagagaatg atgaatgcaa ttaaggaatc ttatgattat aatccaaata aaactaacag gccatttatt tctcagaaaa tccattttcc tgatttttct accagagaca tacataggaa ttatgttgat tgtgtgcgat ggttaggcga tttgatactt tctaagagtg gccgtgccat tttacattcc caccagcaat gtatgagaga tccagtgtct ccgaatcttc gccagcattt gtcttgtgaa aatgccattg tgtgctggaa acctggcaag atggaagatg atatagataa aattaaaccc agtgaatcta atgtgactat tcttgggcga tttgattaca gccagtgtga catttggtac atgaggtttt ctatggattt ctggcaaaag atgcttgcat tgggcaatca agttggcaaa ctttatgttt gggatttaga agtagaagat cctcataaag ccaaatgtac aacactgact catcataaat gtggtgctgc tattcgacaa accagtttta gcagggatag cagcattctt atagctgttt gtgatgatgc cagtatttgg cgctgggatc gacttcgata a. It is sometimes possible for the material contained within the vial of "EED, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
