PLCD1 cdna clone
PLCD1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
PLCD1: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Defects in PLCD1 are the cause of nail disorder non- syndromic congenital type 3 (NDNC3). NDNC3 is a nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase
Chromosomal Location of Human Ortholog: 3p22-p21.3
Cellular Component: cytoplasm; plasma membrane
Molecular Function: GTPase activating protein binding; phosphoinositide phospholipase C activity
Biological Process: inositol phosphate metabolic process; phospholipid metabolic process
Disease: Nail Disorder, Nonsyndromic Congenital, 3
Research Articles on PLCD1
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Product Notes
The PLCD1 plcd1 (Catalog #AAA1275538) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggactcgg gccgggactt cctgaccctg cacggcctac aggatgatga ggatctacag gcgctgctga agggcagcca gctcctgaag gtgaagtcca gctcatggag gagagagcgc ttctacaagt tgcaggagga ctgcaagacc atctggcagg agtcccgcaa ggtcatgcgg accccggagt cccagctgtt ctccatcgag gacattcagg aggtgcgaat ggggcaccgc acggagggtc tggagaagtt cgcccgtgat gtgcccgagg accgctgctt ctccattgtc ttcaaggacc agcgcaatac actagacctc atcgccccat cgccagctga tgcccagcac tgggtgctgg ggctgcacaa gatcatccac cactcaggct ccatggacca gcgtcagaag ctacagcact ggattcactc ctgcttgcga aaagctgaca aaaacaagga caacaagatg agcttcaagg agctgcagaa cttcctgaag gagctcaaca tccaggtgga cgacagctat gcccggaaga tcttcaggga gtgtgaccac tcccagacag actccctgga ggacgaggag attgaggcct tctacaagat gctgacccag cgggtggaga tcgaccgcac cttcgccgag gccgcgggct caggggagac tctgtcggtg gatcagttag tgacgttcct gcagcaccag cagcgggagg aggcggcagg gcctgcgctg gccctctccc tcattgagcg ctacgagccc agcgagactg ccaaggcgca gcggcagatg accaaggacg gcttcctcat gtacttactg tcggctgacg gcagcgcctt cagcctggca caccgccgtg tctaccagga catgggccag ccacttagcc actacctggt gtcctcttca cacaacacct acctgctgga ggaccagcta gccgggccca gcagcactga agcctacatc cgggcactgt gcaaaggctg ccgatgcctg gagcttgact gctgggacgg gcccaaccag gaaccaatca tctaccacgg ctatactttc acttccaaga tcctcttctg cgatgtgctc agggccatcc gggactatgc cttcaaggcg tccccctacc ctgtcatcct atccctggag aaccactgca cactggagca gcagcgcgtg atggcgcggc acctgcatgc catcctgggc cccatgctgt tgaaccgacc actggatggg gtcaccaaca gcctgccctc ccctgagcaa ctgaagggga agatcctgct gaaggggaag aagctcgggg ggctcctgcc ccctggaggg gagggtggcc ctgaggccac tgtggtgtca gacgaagacg aggctgctga gatggaggat gaggcagtga ggagccgtgt gcagcacaag cccaaggagg acaagctcag gctagcacag gagctctctg acatggtcat ttactgcaag agtgtccact ttgggggctt ctccagtcct ggcacccctg gacaggcctt ctacgagatg gcgtccttct ctgagaaccg tgcccttcga ctgctccaag aatcaggaaa cggctttgtc cgccacaacg tggggcacct gagcagaatc tacccggctg gatggagaac agactcctcc aactacagcc ccgtggagat gtggaatggg ggctgccaga tcgtggccct gaatttccag acacctgggc cagagatgga cgtgtaccag ggccgcttcc aggacaacgg ggcctgtggg tacgtgctga agcccgcctt cctgcgagac cccaacggca cctttaaccc ccgcgccctg gctcaggggc cctggtgggc acggaagcgg ctcaacatca gggtcatttc ggggcagcag ctgccaaaag tcaacaagaa taagaattca attgtggacc ccaaagtgac agtggagatc catggcgtga gccgggacgt ggccagccgc cagactgctg tcatcaccaa caatggtttc aacccatggt gggacacgga gtttgcgttt gaggtagttg tgcctgacct tgccctcatc cgcttcttgg tggaagatta tgatgcctcc tccaagaatg acttcattgg ccagagtacc atccccttga acagcctcaa gcaaggatac cgccatgtcc acctcatgtc taagaacggg gaccagcatc catcagccac cctctttgtg aagatctccc tccaggacta g. It is sometimes possible for the material contained within the vial of "PLCD1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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