JMJD6 cdna clone
JMJD6 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
JMJD6: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses. Belongs to the JMJD6 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; Apoptosis; Cell development/differentiation; Receptor, misc.; EC 1.14.11.-; Nucleolus
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: nucleolus; nucleoplasm; nucleus
Molecular Function: histone demethylase activity; histone demethylase activity (H3-R2 specific); histone demethylase activity (H4-R3 specific); identical protein binding; iron ion binding; protein binding; RNA binding; single-stranded RNA binding
Biological Process: peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine; regulation of nuclear mRNA splicing, via spliceosome; sprouting angiogenesis
Research Articles on JMJD6
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Product Notes
The JMJD6 jmjd6 (Catalog #AAA1275318) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaaccaca agagcaagaa gcgcatccgc gaggccaagc ggagtgcgcg gccggagctc aaggactcgc tggattggac ccggcacaac tactacgaga gcttctcgct gagcccggcg gccgtggcgg ataacgtgga aagggcagat gctttacagc tgtctgtgga agaatttgtg gagcggtatg aaagacctta caagcccgtg gttttgttga atgcgcaaga gggctggtct gcgcaggaga aatggactct ggagcgccta aaaaggaaat atcggaacca gaagttcaag tgtggtgagg ataacgatgg ctactcagtg aagatgaaga tgaaatacta catcgagtac atggagagca ctcgagatga tagtcccctt tacatctttg acagcagcta tggtgaacac cctaaaagaa ggaaactttt ggaagactac aaggtgccaa agtttttcac tgatgacctt ttccagtatg ctggggagaa gcgcaggccc ccttacaggt ggtttgtgat ggggccacca cgctccggaa ctgggattca catcgaccct ctgggaacca gtgcctggaa tgccttagtt cagggccaca agcgctggtg cctgtttcct accagcactc ccagggaact catcaaagtg acccgagacg aaggagggaa ccagcaagac gaagctatta cctggtttaa tgttatttat ccccggacac agcttccaac ctggccacct gaattcaaac ccctggaaat cttacaaaaa ccaggagaga ctgtctttgt accaggaggc tggtggcatg ttgtcctcaa tctcgacact actatcgcca tcacccaaaa ttttgccagc agcaccaact tccctgtggt atggcacaag acggtaagag ggagaccaaa gttatcaagg aaatggtata ggattttgaa gcaagagcac cccgagttgg cagtcctcgc agactcggtt gaccttcagg agtccacagg gatagcttcc gacagctcca gcgactcttc cagctcctcc agctccagtt cgtcagactc cgactcagag tgcgagtctg gatccgaggg cgatgggaca gtgcaccgca ggaagaagag gaggacgtgc agcatggtgg gaaacgggga caccacctcc caggacgact gtgtcagcaa agagcgcagc tcctccaggt ga. It is sometimes possible for the material contained within the vial of "JMJD6, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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