EIF2AK4 cdna clone
EIF2AK4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
Uniprot Description
GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.
Protein type: Kinase, protein; Translation; Protein kinase, Other; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; PEK family; GCN2 subfamily
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: polysome
Molecular Function: eukaryotic translation initiation factor 2alpha kinase activity; protein serine/threonine kinase activity; tRNA binding
Biological Process: cellular response to amino acid starvation; inhibition of CREB transcription factor; learning; long-term memory; negative regulation of neuron differentiation; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; positive regulation of adaptive immune response; positive regulation of defense response to virus by host; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translational initiation; T cell activation during immune response; viral protein biosynthetic process
Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive
Research Articles on EIF2AK4
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Product Notes
The EIF2AK4 eif2ak4 (Catalog #AAA1275257) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctgggg gccgtggggc ccccgggcgc ggccgggacg agcctccgga gagctacccg caacgacagg accacgagct acaggccctg gaggccatct acggcgcgga cttccaagac ctgcggccgg acgcttgcgg accggtcaaa gagccccctg aaatcaattt agttttgtac cctcaaggcc taactggtga agaagtatat gtaaaagtgg atttgagggt taaatgccca cctacctatc cagatgtagt tcctgaaata gagttaaaaa atgccaaagg tctatcaaat gaaagtgtca atttgttaaa atctcgccta gaagaactgg ccaagaaaca ctgtggggag gtgatgatct ttgaactggc ttaccacgtg cagtcatttc tcagcgagca taacaagccc cctcccaagt cttttcatga agaaatgctg gaaaggcggg ctcaggagga gcagcagagg ctgttggagg ccaagcggaa agaagagcag gagcaacgtg aaatcctgca tgagattcag agaaggaaag aagagataaa agaagagaaa aaaaggaaag aaatggctaa gcaggaacgt ttggaaattg ctagtttgtc aaaccaagat catacctcta agaaggaccc aggaggacac agaacggctg ccattctaca tggaggctct cctgactttg taggaaatgg taaacatcgg gcaaactcct caggaaggtc taggcgagaa cgtcagtatt ctgtatgtaa tagtgaagat tctcctggct cttgtgaaat tctgtatttc aatatgggga gtcctgatca gctcatggtg cacaaaggga aatgtattgg cagtgatgaa caacttggaa aattagtcta caatgctttg gaaacagcca ctggtggctt tgtcttgttg tatgagtggg tccttcagtg gcagaaaaaa atgggtccat tccttaccag tcaagaaaaa gagaagattg ataagtgcaa aaagcagatt caaggaacag aaacagaatt caactcactg gtaaaattga gccatccaaa tgtagtacgc taccttgcaa tgaatctcaa agagcaagac gactccatcg tggtggacat tttagtggag cacattagtg gggtctctct tgctgcacac ctgagccact caggccccat ccctgtgcat cagcttcgca ggtacacagc tcagctcctg tcaggccttg attatctgca cagcaattct gtggtgcata aggtcctgag tgcatctaat gtcttggtgg atgcagaagg caccgtcaag attacggact atagcatttc taagcgcctc gcagacattt gcaaggagga tgtgtttgag caaacccgag ttcgttttag tgacaatgct ctgccttata aaacggggaa gaaaggagat gtttggcgtc ttggccttct gctgctgtcc ctcagccaag gacaggaatg tggagagtac cctgtgacca tccctagtga cttaccagct gactttcaag attttctaaa gaaatgtgtg tgcttggatg acaaggaaag atggagtccc cagcagttgt tgaaacacag ctttataaat ccccagccaa aaatgcctct agtggaacaa agtcctgaag attctgaagg acaagattat gttgagactg ttattcctag caaccggcta cccagtgctg ccttctttag tgagacacag agacagtttt cccgatactt cattgagttt gaagaattac aacttcttgg taaaggagct tttggagctg tcatcaaggt gtggtacaga gtcattccca gtccccttta g. It is sometimes possible for the material contained within the vial of "EIF2AK4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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