CTSD cdna clone
CTSD cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]
Uniprot Description
CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family.
Protein type: Autophagy; EC 3.4.23.5; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: extracellular matrix; extracellular region; extracellular space; lipid raft; lysosomal lumen; lysosome
Molecular Function: cysteine-type endopeptidase activity; protein binding; serine-type endopeptidase activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; autophagy; collagen catabolic process; protein catabolic process
Disease: Ceroid Lipofuscinosis, Neuronal, 10
Research Articles on CTSD
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Product Notes
The CTSD ctsd (Catalog #AAA1274161) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcagccct ccagccttct gccgctcgcc ctctgcctgc tggctgcacc cgcctccgcg ctcgtcagga tcccgctgca caagttcacg tccatccgcc ggaccatgtc ggaggttggg ggctctgtgg aggacctgat tgccaaaggc cccgtctcaa agtactccca ggcggtgcca gccgtgaccg aggggcccat tcccgaggtg ctcaagaact acatggacgc ccagtactac ggggagattg gcatcgggac gcccccccag tgcttcacag tcgtcttcga cacgggctcc tccaacctgt gggtcccctc catccactgc aaactgctgg acatcgcttg ctggatccac cacaagtaca acagcgacaa gtccagcacc tacgtgaaga atggtacctc gtttgacatc cactatggct cgggcagcct ctccgggtac ctgagccagg acactgtgtc ggtgccctgc cagtcagcgt cgtcagcctc tgccctgggc ggtgtcaaag tggagaggca ggtctttggg gaggccacca agcagccagg catcaccttc atcgcagcca agttcgatgg catcctgggc atggcctacc cccgcatctc cgtcaacaac gtgctgcccg tcttcgacaa cctgatgcag cagaagctgg tggaccagaa catcttctcc ttctacctga gcagggaccc agatgcgcag cctgggggtg agctgatgct gggtggcaca gactccaagt attacaaggg ttctctgtcc tacctgaatg tcacccgcaa ggcctactgg caggtccacc tggaccaggt ggaggtggcc agcgggctga ccctgtgcaa ggagggctgt gaggccattg tggacacagg cacttccctc atggtgggcc cggtggatga ggtgcgcgag ctgcagaagg ccatcggggc cgtgccgctg attcagggcg agtacatgat cccctgtgag aaggtgtcca ccctgcccgc gatcacactg aagctgggag gcaaaggcta caagctgtcc ccagaggact acacgctcaa ggtgtcgcag gccgggaaga ccctctgcct gagcggcttc atgggcatgg acatcccgcc acccagcggg ccactctgga tcctgggcga cgtcttcatc ggccgctact acactgtgtt tgaccgtgac aacaacaggg tgggcttcgc cgaggctgcc cgcctctag. It is sometimes possible for the material contained within the vial of "CTSD, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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