STAU1 cdna clone
STAU1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]
Uniprot Description
STAU: Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 20q13.1
Cellular Component: cytoplasm; dendrite; endoplasmic reticulum; membrane; microtubule associated complex; plasma membrane; stress granule
Molecular Function: protein binding
Biological Process: positive regulation of viral genome replication; positive regulation of viral protein levels in host cell
Research Articles on STAU1
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Product Notes
The STAU1 stau1 (Catalog #AAA1274147) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtctcaag ttcaagtgca agttcagaac ccatctgctg ctctctcagg gagccaaata ctgaacaaga accagtctct tctctcacag cctttgatga gtattccttc tactactagc tctctgccct ctgaaaatgc aggtagaccc attcaaaact ctgctttacc ctctgcatct attacatcca ccagtgcagc tgcagaaagc ataaccccta ctgtagaact aaatgcactg tgcatgaaac ttggaaaaaa accaatgtat aagcctgttg acccttactc tcggatgcag tccacctata actacaacat gagaggaggt gcttatcccc cgaggtactt ttacccattt ccagttccac ctttacttta tcaagtggaa ctttctgtgg gaggacagca atttaatggc aaaggaaaga caagacaggc tgcgaaacac gatgctgctg ccaaagcgtt gaggatcctg cagaatgagc ccctgccaga gaggctggag gtgaatggaa gagaatccga agaagaaaat ctcaataaat ctgaaataag tcaagtgttt gagattgcac ttaaacggaa cttgcctgtg aatttcgagg tggcccggga gagtggccca ccccacatga agaactttgt gaccaaggtt tcggttgggg agtttgtggg ggaaggtgaa gggaaaagca agaagatttc aaagaaaaat gccgccatag ctgttcttga ggagctgaag aagttaccgc ccctgcctgc agttgaacga gtaaagccta gaatcaaaaa gaaaacaaaa cccatagtca agccacagac aagcccagaa tatggccagg ggatcaatcc gattagccga ctggcccaga tccagcaggc aaaaaaggag aaggagccag agtacacgct cctcacagag cgaggcctcc cgcgccgcag ggagtttgtg atgcaggtga aggttggaaa ccacactgca gaaggaacgg gcaccaacaa gaaggtggcc aagcgcaatg cagccgagaa catgctggag atccttggtt tcaaagtccc gcaggcgcag cccaccaaac ccgcactcaa gtcagaggag aagacaccca taaagaaacc aggggatgga agaaaagtaa ccttttttga acctggctct ggggatgaaa atgggactag taataaagag gatgagttca ggatgcctta tctaagtcat cagcagctgc ctgctggaat tcttcccatg gtgcccgagg tcgcccaggc tgtaggagtt agtcaaggac atcacaccaa agattttacc agggcagctc cgaatcctgc caaggccacg gtaactgcca tgatagcccg agagttgttg tatgggggca cctcgcccac agccgagacc attttaaaga ataacatctc ttcaggccac gtaccccatg gacctctcac gagaccctct gagcaactgg actatctttc cagagtccag ggattccagg ttgaatacaa agacttcccc aaaaacaaca agaacgaatt tgtatctctt atcaattgct cctctcagcc acctctgatc agccatggta tcggcaagga tgtggagtcc tgccatgata tggctgcgct gaacatctta aagttgctgt ctgagttgga ccaacaaagt acagagatgc caagaacagg aaacggacca atgtctgtgt gtgggaggtg ctga. It is sometimes possible for the material contained within the vial of "STAU1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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