MRE11A cdna clone
MRE11A cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.
Protein type: Deoxyribonuclease; Cell cycle regulation; DNA-binding; DNA repair, damage
Chromosomal Location of Human Ortholog: 11q21
Cellular Component: cell-cell adherens junction; chromosome, telomeric region; cytoplasm; cytosol; Mre11 complex; nuclear chromosome, telomeric region; nucleoplasm; nucleus; PML body
Molecular Function: 3'-5' exonuclease activity; ATP-dependent DNA helicase activity; DNA binding; double-stranded DNA binding; endodeoxyribonuclease activity; nuclease activity; protein binding; protein C-terminus binding; single-stranded DNA specific endodeoxyribonuclease activity
Biological Process: DNA double-strand break processing; DNA duplex unwinding; DNA recombination; DNA repair; DNA replication; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; intra-S DNA damage checkpoint; meiotic recombination; negative regulation of apoptosis; negative regulation of DNA endoreduplication; positive regulation of interferon type I production; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; regulation of mitotic recombination; response to DNA damage stimulus; sister chromatid cohesion; strand displacement; telomere maintenance via telomerase; telomeric 3' overhang formation
Disease: Ataxia-telangiectasia-like Disorder 1
Research Articles on MRE11A
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Product Notes
The MRE11A mre11a (Catalog #AAA1274080) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgagtactg cagatgcact tgatgatgaa aacacattta aaatattagt tgcaacagat attcatcttg gatttatgga gaaagatgca gtcagaggaa atgatacgtt tgtaacactc gatgaaattt taagacttgc ccaggaaaat gaagtggatt ttattttgtt aggtggtgat ctttttcatg aaaataagcc ctcaaggaaa acattacata cctgcctcga gttattaaga aaatattgta tgggtgatcg gcctgtccag tttgaaattc tcagtgatca gtcagtcaac tttggtttta gtaagtttcc atgggtgaac tatcaagatg gcaacctcaa catttcaatt ccagtgttta gtattcatgg caatcatgac gatcccacag gggcagatgc actttgtgcc ttggacattt taagttgtgc tggatttgta aatcactttg gacgttcaat gtctgtggag aagatagaca ttagtccggt tttgcttcaa aaaggaagca caaagattgc gctatatggt ttaggatcca ttccagatga aaggctctat cgaatgtttg tcaataaaaa agtaacaatg ttgagaccaa aggaagatta g. It is sometimes possible for the material contained within the vial of "MRE11A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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